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Table 1 Vaccination Response of children experiencing repetitive episodes of invasive pneumococcal disease

From: Serologic response to pneumococcal vaccination in children experiencing recurrent invasive pneumococcal disease

Patient Underlying disease Localization of Infection (serotypes) Vaccine (s) given Responder (R) / Non Responder (NR)
1 Complement C2 deficiency Bacteremia ×  2 (6B/34) PPV23 (NR)
2 Complement C2 deficiency Bacteremia ×  2 (12F/4) PPV23 (NR)
3 Syndrome, undefined Bacteremia × 2 (7F/23F) PPV23 multiple (NR)
4 Shunt (Dandy-Walker syndrome) Bacteremia × 2 (19F/19F) PPV23 × 2 (NR)
5 HSCT (MB Gaucher) Bacteremia × 2 (18C/18C) PPV23 (NR)
6 No underlying condition found Bacteremia × 2 (6B/6B) PCV7 × 2, PPV23 PCV7 (R), PPV23 (NR)
7 No underlying condition found Bacteremia × 2 (6B/6B) PCV7 × 3, PPV23 PCV7 (Subnormal (Table 2), PPV23 (NR)
8 No underlying condition found Bacteremia × 2 (6A/24F) PCV13, PPV23 ×  2 PCV13 (R), PPV23 (NR)
9 Complement C2 deficiency Bacteremia × 3 (6B/16F/14) PCV/ × 2, PPV23 PCV7 (R), PPV23 (NR)
10 Syndrome with malabsorption Bacteremia × 3 (14/19A/19A) PCV7, PPV23 PCV7 (R), PPV23 (NR)
11 Toll-Like receptor signaling defect Bacteremia × 5 (15C/7/7/38/NTpn) PCV7 × 3 PCV7 (Subnormal) (Table 2)
12 Leukemia Bacteremia × 4 (18C/8/8/8) PCV7 ×  2, PPV23 R
13 No underlying condition found Meningitis × 2 (14/6B) PCV7 ×  3 R
14 Univentricular heart Bacteremia × 2 (33F/33F) PPV23 R
15 Complement C2 deficiency Meningitis × 2 (4/14) PPV23 x multiple R
16 Klippel Trenaunay syndrome Bacteremia × 3 (6A/24F/24F) PPV23 R
17 Asplenia congenitalis Meningitis × 2 (6B/6A) PPV23 R
18 Complement C2 deficiency Bacteremia × 2 (9 V/NTpn) PCV7 × 2, PPV23 R
19 No underlying condition found Meningitis/bacteremia (19F/1) PCV7 × 2 R
20 Hepatic disease (Biliary atresia) Bacteremia × 2 (9 N/23A) PCV7 × 2 R
21 CNS tumor, chemo treatment Bacteremia ×  2 (9 V/1) PCV7 ×  2 R
22 HSCT (myelodysplasia) Bacteremia × 2 (6B/6B) PCV23 R
23 Complement C2 deficiency Bacteremia × 2 (6B/38) PPV23 R
24 Asplenia congenitalis Meningitis × 2 (23F/15C) PCV7 × 2, PPV23 R
25 No underlying condition found Bacteremia × 2 (19A/19A) PCV13 R
26 Hepatic disease (Biliary atresia) Bacteremia × 2 (9 N/23A) PCV7 R
  1. HSCT Haematopoietic Stem Cell Transplantation, PCV Pneumococcal conjugate vaccine, PPV Pneumococcal polysaccharide vaccine, NTPn Non typeable S.pneumococcus, Serotypes in bold are included in the vaccine (s) given to the particular child