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Table 3 Rates of ACP and IPD

From: Clinical and economic burden of pneumococcal disease in US adults aged 19–64 years with chronic or immunocompromising diseases: an observational database study

 

ACP

IPD

Variable

Person-Years

Rate per 100, 000 person-years

Rate ratio (95% CI)

Rate per 100, 000 person-years

Rate ratio (95% CI)

 Overall

57,108,315.72

656.40

3.62

Age group

 19–49

35,360,219.65

438.26

1.77

 50–64

21,748,096.07

1011.08

6.63

Gender

 Female

27,290,491.17

658.00

3.77

 Male

29,817,824.55

654.93

3.48

Health plan type

 Fee-for-service

1,159,288.49

1395.17

10.44

 PPO/EPO

36,123,603.49

646.15

3.58

 HMO

6,943,639.48

620.81

3.25

 POS

4,046,790.82

705.74

3.56

HDHP/CDHP

6,592,500.88

566.14

2.76

 Unknown

2,242,492.56

726.11

4.50

Medical conditions

 Healthy

47,370,548.67

429.65

1.00

1.91

1.00

 Any at-risk or high-risk condition

9,737,767.05

1759.46

4.10 (4.07–4.12)

11.92

6.23 (5.72–6.80)

At-risk conditions

 Overall

7,119,125.33

1573.40

3.66 (3.64–3.69)

8.91

4.66 (4.21–5.15)

 Asthma

1,596,160.50

1783.09

4.15 (4.10–4.20)

7.71

4.03 (3.34–4.86)

 Chronic heart disease

1,432,517.29

2343.78

5.46 (5.39–5.52)

11.38

5.95 (5.04–7.03)

 Chronic lung disease

1,007,145.18

3530.77

8.22 (8.13–8.31)

20.16

10.54 (9.13–12.33)

 Chronic liver disease

607,949.48

1603.75

3.73 (3.66–3.81)

13.82

7.22 (5.78–9.03)

 Diabetes mellitus

3,656,304.75

1396.74

3.25 (3.22–3.28)

9.03

4.72 (4.16–5.35)

Number of at-risk conditions

 1

6,089,016.03

1251.81

2.91 (2.89–2.94)

6.98

3.65 (3.25–4.10)

  ≥ 2

1,030,109.30

3474.29

8.09 (8.00–8.18)

20.29

10.61 (9.13–12.33)

High-risk conditions

 Overall

2,618,641.72

2265.30

5.27 (5.22–5.32)

20.12

10.52 (9.45–11.72)

 Chronic renal disease

424,677.27

4045.19

9.42 (9.27–9.56)

41.44

21.67 (18.44–25.47)

 Cancer

1,825,298.26

2132.14

4.96 (4.91–5.02)

18.79

9.83 (8.68–11.13)

 Asplenia

40,691.59

3801.77

8.85 (8.42–9.30)

22.12

11.56 (6.00–22.30)

 HIV

108,115.60

1748.13

4.07 (3.89–4.26)

33.30

17.41 (12.48–24.29)

 Organ transplant

522,834.47

1611.03

3.75 (3.67–3.83)

8.03

4.20 (3.08–5.72)

Number of high-risk conditions

 1

2,325,408.37

2209.68

5.14 (5.09–5.19)

19.44

10.16 (9.08–11.38)

  ≥ 2

293,233.35

2706.38

6.30 (6.16–6.44)

25.58

13.37 (10.57–16.92)

  1. ACP all-cause pneumonia, HDHP/CDHP High Deductible/Consumer Driven Health Plan, CI confidence interval, HIV human immunodeficiency virus, HMO Health Maintenance Organization, IPD invasive pneumococcal disease, POS Point of Service, PPO/EPO Preferred/Exclusive Provider Organization