Fig. 1

Profiles of initial therapy and salvage therapy in 44 difficult-to-treat cryptococcal meningitis patients. AmB amphotericin B; 5FC flucytosine; Vor voriconazole; L-Flu low dose fluconazole (≤ 400 mg/day); H-Flu high dose fluconazole (800 mg/day); CR complete response; PR partial response; DILI drug induced liver injury. Addition or removal of 5FC during initial and salvage therapy were not listed. An example for reading the figure: * means that the patient received AmB and flucytosine for a duration of 23 days as induction therapy, followed by consolidation therapy with low dose fluconazole for 142 days, and then switched to salvage therapy with high dose fluconazole for 246 days, and finally achieved partial response at the end of salvage therapy