Skip to main content

Table 1 Baseline characteristics, signs and symptoms of 44 cryptococcal meningitis patients treated with high dose fluconazole for salvage therapy

From: High dose fluconazole in salvage therapy for HIV-uninfected cryptococcal meningitis

Variables

No. (%) of patients

Sex, male

28 (63.6)

Age, years

44 (range, 16–73)

Predisposing factors

 Evans syndrome

4 (9.1)

 MDS

1 (2.3)

 ITP

1 (2.3)

 Lymphoma

1 (2.3)

 Solid tumora

2 (4.5)

 SLE

5 (11.4)

 Cirrhosis

2 (4.5)

 Liver transplantation

1 (2.3)

 Splenectomy

1 (2.3)

 Type 2 diabetes mellitus

2 (4.5)

 Steroids or immunosuppressants

10 (22.7)

Headache

44 (100)

Fever

32 (72.7)

Vomiting

32 (72.7)

Meningeal irritation

32 (72.7)

Seizure

16 (36.4)

Altered mental statusb

12 (27.3)

Cranial nerve defect

 Impaired vision

16 (36.4)

 Diplopia

8 (18.2)

 Visual field defect

8 (18.2)

 Ophthalmodynia

3 (6.8)

 Hearing impairment

18 (40.9)

 Facial paralysis

3 (6.8)

Limb weakness

14 (31.8)

uracratia

3 (6.8)

Dysuria

3 (6.8)

  1. MDS myelodysplastic syndrome; SLE systemic lupus erythematosus; ITP idiopathic thrombocytopenia
  2. aIncluding 1 gastric cancer and 1 cholangiocellular carcinoma
  3. bPatients with scores less than 15 by Glasgow Coma Scale