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Table 3 High dose fluconazole related adverse events in 44 cryptococcal meningitis patients

From: High dose fluconazole in salvage therapy for HIV-uninfected cryptococcal meningitis

Adverse eventsa

No. (%) of patients (N = 44)

Liver dysfunction

 GGT

10 (22.7)

 ALT

5 (11.4)

 AST

4 (9.1)

 ALP

1 (2.3)

Hematocytopenia

 Anemia

1 (2.3)

 Neutropenia

1 (2.3)

 Thrombocytopenia

1 (2.3)

Hypokalemia

3 (6.8)

Nausea and vomitting

5 (11.4)

Constipation

3 (6.8)

Dry mouth

2 (4.5)

Dry eyes

1 (2.3)

Skin lesion

2 (4.5)

Numbness of upper limb

1 (2.3)

Thrombosis of lower limb

1 (2.3)

  1. GGT gama-glutamyltransferase; ALT alanine aminotransferase; AST aspartate aminotransferase; ALP alkaline phosphatase
  2. aAll laboratory abnormalities were grade 1 or grade 2 only