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Table 4 Univariate and multivariate analysis of factors associated with 1-year mortality among 44 cryptococcal meningitis patients

From: High dose fluconazole in salvage therapy for HIV-uninfected cryptococcal meningitis

Factor

Univariate Analysis

Multivariate Analysis

Total No. of patients

No. (%) of patients who died

P-valueb

P-value

RR (95% CI)

Age ≥ 60 years

12

4 (33.3)

0.022

  

Initial AmB course < 6 weeks

10

3 (30.0)

0.095

  

Salvage therapy without 5FC

13

3 (23.1)

0.196

  

Serum albumin level < 35 g/L

13

5 (38.5)

0.001

0.014

16.23 (1.78–148.19)

eGFR < 60 mL/min/1.73m2

8

3 (37.5)

0.015

  

CSF WBC count < 10 /mm3a

14

4 (28.6)

0.012

  

CSF glucose level < 36 mg/dLa

22

1 (4.5)

0.127

  

CSF CrAg titer ≥ 1280a

17

4 (23.5)

0.058

0.048

9.30 (1.02–84.73)

  1. AmB Amphotericin B; 5FC flucytosine; eGFR estimated glomerular filtration rate; CrAg cryptococcal capsular antigen; CSF cerebrospinal fluid; WBC white blood cell
  2. aData of CSF WBC count, CSF glucose level and CSF cryptococcal antigen titter was unavailable in 1 dead patient
  3. bFactor entered the initial univariate analysis included male, age ≥ 60 years, time before diagnosis ≥60 days, predisposing factors, pulmonary involvement, seizure, altered mental status, parenchyma lesions of brain MRI, initial AmB course < 6 weeks, salvage therapy without 5FC, serum albumin level < 35 g/L, eGFR < 60 mL/min/1.73m2, CSF WBC count < 10 /mm3, CSF protein level > 500 mg/dL, CSF glucose level < 36 mg/dL, CSF CrAg titer ≥1280. Only predictors with a P-value less than 0.2 were listed in the table