Fig. 4

Trial sequential analysis of evidence for the effectiveness of chlorhexidine (CHG) bathing, in adult intensive care patients, to reduce infection. BSI = Blood Stream Infection, CLABSI = Central Line Associated Blood Stream Infection, MDRO = Multi-Drug Resistant Organism, VAP = Ventilator Associated Pneumonia, and CAUTI – Catheter Associated Urinary Tract Infections. RRR = Risk rate reduction. Estimates above the upper boundary (broken line) suggest superiority, while those below the lower boundary, suggest inferiority of CHG-bathing to prevent infection. The required heterogeneity information size estimated using the approach suggested by Thorlund et al [14]