Evidence for the effectiveness of chlorhexidine bathing and health care-associated infections among adult intensive care patients: a trial sequential meta-analysis

Table 2 Summary of specific outcomes of hospital acquired infections among adults admitted to intensive care, from randomised controlled trials

Outcome of interest	no. of trials [ref] (no. of patients)	Summary estimate, Risk Ratio (95% CI) [test of heterogeneity, p-value]	Baseline risk (among control period)	Estimated information size¹
BSI	4-trials [6, 21, 30] (n = 18,290)	MH (FE) RR = 0.75 (0.63, 0.91) [I² = 49%, het test, p = 0.117]	6 / 1000 ICU days	62,700 (HIS)
CLABSI	3-trials [6, 21, 28] (n = 17,540)	MH (FE) RR = 0.56 (0.35, 0.89) [I² = 9%, het test, p = 0.331	3 / 1000 lines days	62,700 (HIS)
MRDO	2-trials [6, 21] (n = 17,152)	MH (FE) RR = 0.82 (0.69, 0.98) [I² = 0%, het test, p-value = 0.416]	6 / 1000 ICU days	34,000 (IS)
VAP	3-trials [21, 30] (n = 10,564)	MH (FE) RR = 1.55 (0.79, 3.01) [I² = 17%, het test, p-value = 0.213]	5 / 1000 MV days	40,950 (HIS)
CAUTI	3-trials [21, 28, 29] (n = 9983)	MH (FE) RR = 0.77 (0.52, 1.14) [I² = 0%, het test, p-value = 0.539)	6 / 1000 catheter days	32,000 (IS)

Note: BSI Blood Stream Infection, CLABSI Central Line Associated Blood Stream Infection, MDRO Multi-Drug Resistant Organism, VAP Ventilator Associated Pneumonia, and CAUTI Catheter Associated Urinary Tract Infections, CI confidence interval, MH Cochrane-Mantel-Haenszel, FE Fixed Effect. Heterogeneity Information size estimated using the approach suggested by Thorlund et al [14]. HIS Heterogeneity adjusted Information Size (I² < 0%), IS (Information Size, I² > 0%)

ISSN: 1471-2334