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Table 2 Bivariate analysis of the factors associated with treatment initiation in adult patients with nontuberculous mycobacterial lung disease without systemic immunodeficiency

From: A retrospective study of factors associated with treatment decision for nontuberculous mycobacterial lung disease in adults without altered systemic immunity

Tested variables

Treated patients (n=25)

Untreated patients (n=26)

 

P-value

OR [95% CI]

Clinical criteria

 BMI < 18 (kg/m2)

13/24 (54.2)

5/23 (21.7)

 

0.026

4.25 [1.18-15.2]

 Weight loss > 5%

17 (68)

10 (38.5)

 

0.05

3.4 [1.07-10.77]

 fatigue

13 (52)

7 (27)

 

0.071

2.94 [0.9-9.46]

 chronic cough

16 (64)

14 (54)

 

0.572

1.52 [0.49-4.69]

 night sweats

5 (20)

3 (11.5)

 

0.465

1.92 [0.41-9.05]

 hemoptysis

8 (32)

1 (3.8)

 

0.026

11.8 [1.3-102.8]

Microbiological criteria

 AFB-positive sputum sample on direct examination

13 (52)

8 (30.8)

 

0.160

2.44 [0.77-7.65]

 NTM-positive culture NTM on lower respiratory tract sample

2 (1-2.3)

1 (1-1.8)

 

0.044

1.79 [1-3.2]

Functional criteria

 FEV1 (L)

1.6 (1.2-2.2)

1.9 (1.2-2.5)

 

0.554

0.72 [0.34-1.51]

Immunological and nutritional status

 total lymphocyte count (G/L)

1.3 (1.2-1.7)

1.4 (1.1-2.1)

 

0.388

0.95 [0.86-1.04]

 CD4+ lymphocyte count (%)

54 (4.5-61.5)

40 (37.8-44.3)

 

0.031

1.07 [0.95-1.21]

 serum albumin (mg/L)

39.5 (36-43)

39 (33-42.5)

 

0.481

1.05 [0.97-1.14]

 serum pre-albumin (mg/L)

0.21 (0.15-0.24)

0.22 (0.15-0.25)

 

0.974

1.25 [0-1.48]

 vitamin D deficiency

6/10 (60)

6/7 (86)

 

0.338

0.25 [0.02-2.95]

Co-infection(s)

Mycobacterium tuberculosis

1 (4)

1 (4)

 

0.35

1.04 [0.06-17.6]

Pseudomonas spp.

2 (8)

3 (11.5)

 

1

0.68 [0.1-4.4]

Aspergillus spp.

15 (60)

5 (19.2)

 

0.004

6.3 [1.8-22.2]

Radiologic features at diagnosis

 nodule(s) (≥ 10mm)

12 (48)

7/23 (30)

 

0.25

2.11 [0.65-6.9]

 cluster(s) of micronodules (< 5mm)

16 (64)

10/23 (44)

 

0.246

2.31 [0.72-7.4]

 cavitation(s)

18 (72)

8/23 (35)

 

0.019

4.82 [1.42-16.4]

 bronchiectasis

14 (56)

11/23 (48)

 

0.773

1.39 [0.45-4.3]

 emphysema

9 (36)

11/23 (48)

 

0.559

0.61 [0.19-1.95]

Radiologic review

 regression

8/23 (35)

4/13 (31)

 

1

1.2 [0.28-5.15]

 stabilization

9/23 (39)

6/13 (46)

 

0.736

0.75 [0.19-2.97]

 worsening

6/23 (26)

3/13 (23)

 

1

1.18 [0.24-5.8]

  1. NOTE Data are No. (%) of patients, unless otherwise indicated. Denominators have been stipulated for variables with missing data. Odds ratios (OR) were determined by conditional logistic regression with 95% confidence interval (95% CI)
  2. Abbreviations: AFB, acid-fast bacilli; BMI, body mass index; CI, confidence interval; FEV1, forced expiratory volume in 1 second; NTM, nontuberculous mycobacteria; OR, odds ratio