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Table 1 Characteristics associated with mortality during tuberculosis treatment

From: Development and validation of a risk score to predict mortality during TB treatment in patients with TB-diabetes comorbidity

 

Total

Completed

Deceased

Unadjusted OR

Adjusted OR

Adjusted p

(N = 1227)

(n = 1115)

(n = 112)

(95% CI)

(95% CI)

 

Age ≥ 65 (years)

322 (26.2)

260 (23.3)

62 (55.4)

4.08 (2.74, 6.07)

4.85 (3.00, 7.85)

< 0.001

Male gender

790 (64.4)

712 (63.9)

78 (69.6)

1.30 (0.85, 1.98)

  

Race/Ethnicity

 White

90 (7.3)

78 (7.0)

12 (10.7)

1.80 (0.93, 3.48)

  

 Black

136 (11.1)

119 (10.7)

17 (15.2)

1.67 (0.95, 2.95)

  

 Hispanic

827 (67.4)

762 (68.3)

65 (58.0)

(reference

  

 Asian

164 (13.4)

147 (13.2)

17 (15.2)

1.36 (0.77, 2.38)

  

 Other

10 (0.8)

9 (0.8)

1 (0.9)

1.30 (0.16, 10.44)

  

US-born

450 (40.0)

396 (38.7)

54 (51.9)

1.70 (1.14, 2.50)

1.64 (1.03, 2.62)

0.04

Homeless

41 (3.3)

33 (3.0)

8 (7.1)

2.52 (1.14, 5.60)

2.88 (1.05, 7.88)

0.04

Inmate in a correctional institution

35 (3.3)

33 (3.4)

2 (2.1)

0.61 (0.14, 2.58)

  

Resident of long-term care facility

21 (1.7)

14 (1.3)

7 (6.3)

5.24 (2.07, 13.28)

1.50 (0.49, 4.58)

0.47

IDU addicts

15 (1.2)

10 (0.9)

5 (4.5)

5.16 (1.73, 15.38)

7.25 (1.64, 31.98)

0.01

Non-IDU addicts

73 (5.9)

64 (5.7)

9 (8.0)

1.43 (0.69, 2.97)

  

Excessive alcohol consumption

182 (14.8)

174 (15.6)

8 (7.1)

0.42 (0.20, 0.87)

0.46 (0.20, 1.07)

0.07

Organ transplant receiver

8 (0.7)

7 (0.6)

1 (0.9)

1.43 (0.17, 11.70)

  

Chronic kidney failure

60 (4.9)

38 (3.4)

22 (19.6)

6.93 (3.93, 12.22)

7.00 (3.59, 13.62)

< 0.001

Immunosuppression (medical condition or medication)

35 (2.9)

30 (2.7)

5 (4.5)

1.69 (0.64, 4.45)

  

Pulmonary TB

1110 (90.5)

1011 (90.7)

99 (88.4)

0.78 (0.42, 1.45)

  

TB meningitis

10 (0.8)

7 (0.6)

3 (2.7)

4.36 (1.11, 17.09)

7.25 (1.54, 34.08)

0.01

Miliary TB

33 (2.7)

25 (2.3)

8 (7.1)

3.32 (1.46, 7.55)

3.79 (1.41, 10.21)

0.01

TB-CXR

1084 (88.3)

983 (88.2)

101 (90.2)

1.23 (0.64, 2.36)

  

Cavitation on CXR

509 (47.0)

479 (48.7)

30 (29.7)

0.44 (0.28, 0.69)

0.69 (0.41, 1.15)

0.15

AFB smear (+)

684 (61.4)

636 (61.6)

48 (58.5)

0.88 (0.56, 1.39)

1.74 (1.01, 2.98)

0.04

Culture (+)

863 (70.3)

799 (71.7)

64 (57.1)

2.52 (1.73, 3.68)

  

TB case verified by positive culture, NAA, or AFB smear

1066 (86.9)

964 (86.5)

102 (91.1)

1.60 (0.82, 3.13)

  

HIV status (+)

23 (1.9)

15 (1.3)

8 (7.1)

7.40 (3.04, 18.03)

11.07 (3.66, 33.46)

< 0.001

MDR-TB

10 (0.8)

8 (0.7)

2 (1.8)

2.42 (0.51, 11.54)

  

Mtb East Asian lineage

128 (13.2)

114 (13.0)

14 (15.2)

1.20 (0.66, 2.20)

  
  1. CXR chest radiograph, TB-CXR abnormalities on CXR consistent with tuberculosis, MDR-TB Multi-drug resistant TB, NAA Nucleic Acid Amplification; Excessive alcohol consumption, excessive alcohol consumption in the past 12 months; Mtb, Mycobacterium tuberculosis