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Table 2 Resource use and acquisition costs

From: Cost-effectiveness analysis of isavuconazole versus voriconazole for the treatment of patients with possible invasive aspergillosis in Sweden

Resource use item

Costs (SEK)

Drug costsa

 -Isavuconazoleb (200 mg vial), 200 mg/day (maintenance dose)

5311

 -Isavuconazoleb (14-pack of 100 mg capsules), 200 mg/day (maintenance dose)

7067

 -Voriconazolec (200 mg vial), 2 × 4 mg/kg/day (maintenance dose)

1167

 -Voriconazoled (56-pack of 200 mg capsules), 400 mg/day (maintenance dose)

8008

 -L-AmB (50 mg vial, 10 vials), 5 mg/kg/day

15,869

 -Posaconazolee (96-pack of 100 mg tablets), 300 mg/day

27,938

Hospitalisation costs/dayf

7006

Monitoring cost/unitg

611

Adverse event costs by system order class/event

 -Cardiac (i.e., cardiac arrest, tachycardia)h

18,966

 -Hepatobiliary (i.e., hyperbilirubinemia, abnormal hepatic function, jaundice, cholestasis)i

3863

 -Nephrotoxicityj

89,316

  1. L-AmB liposomal amphotericin B, SEK Swedish krona
  2. aDrug retail prices were taken from the TLV price list for oral isavuconazole, oral voriconazole (generic), liposomal amphotericin-B and posaconazole [27]; the retail prices of IV isavuconazole and voriconazole (generic) were taken from Apoteket.se [28] (March 2018)
  3. bIV and oral isavuconazole loading dose was 200 mg every 8 h on days 1 and 2; maintenance dose was initiated from day 3 onwards
  4. cIV voriconazole loading dose was 6 mg/kg every 12 h on day 1, maintenance dose was initiated from day 2 onwards
  5. dOral voriconazole loading dose was 400 mg/kg on day 1, maintenance dose was initiated from day 2 onwards
  6. ePosaconazole loading dose was 300 mg twice daily on day 1, maintenance dose was initiated from day 2 onwards
  7. fCosts taken from South Sweden Price list [29]; Inpatient daily cost at haematology clinic. Code: VD010 (p. 50)
  8. gCost of liver function test taken from South Sweden Price list [29]
  9. hCosts taken from South Sweden Price list [29]: Cardiac arrest uncomplicated. Code: E48E: 43,228 SEK (29%) and tachycardia: Arrhythmia uncomplicated inpatient [Code: E65E) 8976 SEK (71%)
  10. iCosts taken South Sweden Price list [29]: Physician visit liver/gallbladder. Code: G99O 3863 SEK
  11. jCosts taken from South Sweden Price list [29]: Inpatient day at nephrology dept. Code: VD010 9924 SEK. Based on Bruynesteyn et al., 2007, 9 incremental days due to nephrotoxity were applied