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Table 3 Estimation of diagnostic validity of LF-RPA assay with 114 CSF specimens

From: Development of a lateral flow recombinase polymerase amplification assay for rapid and visual detection of Cryptococcus neoformans/C. gattii in cerebral spinal fluid

 

Culture/India ink staining

Performance characteristics (%)

Positive

Negative

Se

Sp

PPV

NPV

LF-RPA

Pos

40

3

95.2a

95.8b

93.0c

97.2d

Neg

2

69

CrAg Lateral Flow Assay

Pos

42

0

100e

100f

100

100

Neg

0

72

  1. Pos: positive; Neg: negative; Se: sensitivity; Sp: specificity; PPV: positive predictive value; NPV: negative predictive value; CI: confidence interval.
  2. a 95% CI: 83.84%-99.42%; b 95% CI: 88.30%-99.13%; c 95% CI: 81.46%-97.59%; d 95% CI: 89.91%-99.26%; e 95% CI: 91.59%-100.00%; f 95% CI: 95.01%-100.00%.