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Table 2 Mutations in pncA gene of M. tuberculosis in 51 isolates

From: Pyrazinamide resistance and mutations in pncA among isolates of Mycobacterium tuberculosis from Khyber Pakhtunkhwa, Pakistan

Nucleotide position

Codon Change

A.A change

Mutation Type

TBDReaMDB

GMTV Database

Reported (literature)

No. of isolates

33C > A

11.AAC / AAA

uASN11LYS

Non-synonymous

Unreported

Unreported

No

1

35A > C

12.GAC/GCC

aASP12ALA

Non-synonymous

reported

reported

–

2

53C > A

18.TCG/TAG

SER 18 STOP

non-sense

Unreported

Unreported

No

1

56 T > G

19.CTG/CGG

uLEU19ARG

Non-synonymous

reported

Unreported

–

1

137C > T

46.GCA/GTA

uALA46VAL

Non-synonymous

reported

reported

–

1

161C > T

54.CCG/CTG

aPRO54LEU

Non-synonymous

reported

reported

–

1

170A > C

57.CAC/CCC

aHIS57PRO

Non-synonymous

reported

Unreported

–

1

194_203

Del CCTCGTCGTG

FRAMSHIPT

FRAMSHIPT

Unreported

Unreported

No

1

202 T > C

68.TGG/CGG

aTRP68ARG

Non-synonymous

reported

reported

–

1

205C > A

69.CCA/ACA

uPRO69THR

Non-synonymous

Unreported

Unreported

No

3

211C > T

71.CAT/TAT

aHIS71TYR

Non-synonymous

reported

reported

–

3

212A > G

71.CAT/ CGT

aHIS71ARG

Non-synonymous

reported

reported

–

1

226A > C

76.ACT/CCT

aTHR76PRO

Non-synonymous

reported

reported

–

1

286A > C

96.AAG/CAG

aLYS96GLN

Non-synonymous

reported

Unreported

–

4

317–18

Del TC

uFRAMSHIPT

FRAMSHIPT

Unreported

Unreported

No

3

331G > T

111. GAG/TAG

STOP

Non-sense

Unreported

Unreported

No

1

359 T > G

120. CTG/CGG

uLEU120ARG

Non-synonymous

Unreported

reported

–

1

368G > C

123. CGC/CCC

aARG123PRO

Non-synonymous

Unreported

reported

–

1

376G > A

126. GAT/AAT

uASP126ASN

Non-synonymous

Unreported

Unreported

No

2

385G > A

129. GAT/AAT

uASP129ASN

Non-synonymous

Unreported

Unreported

[7]

1

391G > T

131. GTC/TTC

uVAL131PHE

Non-synonymous

Unreported

reported

–

1

398 T > C

133. ATT/ACT

aILEU133THR

Non-synonymous

Unreported

reported

–

2

419G > A

140. CGC/CAC

uARG140HIS

Non-synonymous

Unreported

Unreported

No

2

422A > C

141. CAG/CCG

uGLN141PRO

Non-synonymous

Unreported

reported

–

3

430G > A

144. GAG/AAG

uGLU144LYS

Non-synonymous

Unreported

Unreported

No

1

437C > T

146. GCG/GTG

aALA146VAL

Non-synonymous

reported

reported

–

1

449G > C

150. GGC/GCC

uGLY150ALA

Non-synonymous

Unreported

Unreported

No

1

461G > C

154. AGG/ACG

uARG154THR

Non-synonymous

Unreported

Unreported

[36]

1

470 T > G

157. GTG/GGG

aVAL157GLY

Non-synonymous

Unreported

Unreported

[9, 37, 38]

2

508G > C

170. GCC/CCC

uALA170PRO

Non-synonymous

Unreported

Unreported

No

1

519G > A

173. GAG/GAA

uGLU173GLU

synonymous

Unreported

Unreported

No

1

522G > A

174. GAG/GAA

uGLU173GLU

synonymous

Unreported

Unreported

No

1

530

DEL C

uFRAMSHIPT

FRAMSHIPT

Unreported

Unreported

No

3

535A > T

179. AGC/TGC

uSER179CYS

Non-synonymous

Unreported

Unreported

[39]

4

535A > G

179. AGC/GGC

uSER179GLY

Non-synonymous

Unreported

Unreported

No

1

538G > T

180. GTC/TTC

uVAL180PHE

Non-synonymous

reported

Unreported

–

1

  1. TBDReaMDB Tuberculosis Drug Resistance Mutation Database
  2. GMTV, Genome-wide Mycobacterium tuberculosis variation (GMTV): a, Mutations conferring PZAr with very high confidence (category-A). u, mutations with unclear role (category D) (Miotto et al., 2014)