|  |  | HIV-positive (N = 398) |  |  |  | HIV-negative (N = 196) |  | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Unadjusted | Â | Adjusted | Â | Â | Unadjusted | Adjusted | Â | |||||||
Deaths n/N (%) | HR | 95% CI | p | aHR | 95% CI | p | Deaths n/N (%) | HR | 95% CI | p | aHR | 95% CI | p | |
Age (per additional year) |  | 0.98 | 0.95–1.02 | 0.303 | – | – | – |  | 1.03 | 0.99–1.07 | 0.142 | – | – | – |
Sex | ||||||||||||||
 Men | 15/152 (9.0) | Ref |  |  |  |  |  | 4/88 (4.5) | Ref |  |  |  |  |  |
 Women | 17/231 (7.4) | 0.81 | 0.40–1.62 | 0.550 | – | – | – | 4/108 (3.7) | 0.79 | 0.20–3.15 | 0.736 | – | – | – |
BMI (Kg/m2) | ||||||||||||||
  > =17 | 11/281 (3.9) | Ref |  |  | Ref |  |  | 6/173 (3.5) | Ref |  |  |  |  |  |
  < 17 | 21/117 (18.0) | 4.91 | 2.36–10-18 | < 0.001 | 3.55 | 1.51–8.35 | 0.004 | 2/23 (8.7) | 2.41 | 0.49–11.93 | 0.282 | – | – | – |
Severely ill | ||||||||||||||
 No | 15/320 (4.7) | Ref |  |  | Ref |  |  | 7/178 (3.9) | Ref |  |  | – |  |  |
 Yes | 17/75 (22.7) | 5.32 | 2.66–10.66 | < 0.001 | 2.67 | 1.17–6.12 | 0.020 | 1/17 (5.9) | 1.49 | 0.18–12.10 | 0.710 | – | – | – |
TB history | ||||||||||||||
 No | 19/286 (6.6) | Ref |  |  |  |  |  | 7/154 (4.5) | Ref |  |  |  |  |  |
 Yes | 13/112 (11.6) | 1.86 | 0.92–3.76 | 0.086 | – | – | – | 1/42 (2.4) | 0.51 | 0.06–4.17 | 0.532 | – | – | – |
CD4 count (cells/mL) | ||||||||||||||
  > =200 | 9/247 (3.6) | Ref |  |  | Ref |  |  |  | – | – | – | – | – | – |
  < 200 | 20/129 (15.5) | 4.54 | 2.06–9.97 | < 0.001 | 3.21 | 1.42–7.28 | 0.005 |  | – | – | – | – | – | – |
ART | ||||||||||||||
 Not initiated | 6/58 (10.3) | Ref |  |  | Ref |  |  |  | – | – | – | – | – | – |
 Initiated before study | 17/184 (9.2) | 0.82 | 0.32–2.09 | 0.680 | 0.74 | 0.27–2.07 | 0.573 |  | – | – | – | – | – | – |
 Initiated during study | 6/132 (4.5) | 0.37 | 0.12–1.14 | 0.084 | 0.19 | 0.05–0.65 | 0.008 |  | – | – | – | – | – | – |
Chest X-ray | ||||||||||||||
 Normal | 3/62 (4.8) | Ref |  |  |  |  |  |  |  |  |  |  |  |  |
 Possible TB | 12/164 (7.3) | 1.55 | 0.43–5.50 | 0.496 | – | – | – |  | – | – | – | – | – | – |
 Suggestive TB | 3/47 (6.4) | 1.31 | 0.26–6.48 | 0.742 | – | – | – |  | – | – | – | – | – | – |
TB treatment | ||||||||||||||
 No TB treatmenta | 6/157 (3.8) | Ref |  |  | Ref |  |  | 3/114 (2.6) | Ref |  |  | Ref |  |  |
 Empirical treatment | 11/100 (11.0) | 3.04 | 1.12–8.21 | 0.029 | 2.51 | 0.79–7.90 | 0.115 | 4/31 (12.9) | 4.85 | 1.08–21.67 | 0.039 | 4.85 | 1.08–21.67 | 0.039 |
 Treatment based on confirmed TB | 15/141 (10.6) | 2.76 | 1.07–7.12 | 0.036 | 1.25 | 0.37–4.21 | 0.718 | 1/51 (2.0) | 0.77 | 0.08–7.41 | 0.822 | 0.77 | 0.08–7.41 | 0.822 |