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Table 2 Univariate and multivariate Cox regression analysis of the association between treatment decision for tuberculosis and mortality in the six months after the first consultation in HIV-positive and HIV-negative patients with signs and symptoms of TB

From: Mortality in the first six months among HIV-positive and HIV-negative patients empirically treated for tuberculosis

   

HIV-positive (N = 398)

   

HIV-negative (N = 196)

 

Unadjusted

 

Adjusted

  

Unadjusted

Adjusted

 

Deaths n/N (%)

HR

95% CI

p

aHR

95% CI

p

Deaths n/N (%)

HR

95% CI

p

aHR

95% CI

p

Age (per additional year)

 

0.98

0.95–1.02

0.303

–

–

–

 

1.03

0.99–1.07

0.142

–

–

–

Sex

 Men

15/152 (9.0)

Ref

     

4/88 (4.5)

Ref

     

 Women

17/231 (7.4)

0.81

0.40–1.62

0.550

–

–

–

4/108 (3.7)

0.79

0.20–3.15

0.736

–

–

–

BMI (Kg/m2)

  > =17

11/281 (3.9)

Ref

  

Ref

  

6/173 (3.5)

Ref

     

  < 17

21/117 (18.0)

4.91

2.36–10-18

< 0.001

3.55

1.51–8.35

0.004

2/23 (8.7)

2.41

0.49–11.93

0.282

–

–

–

Severely ill

 No

15/320 (4.7)

Ref

  

Ref

  

7/178 (3.9)

Ref

  

–

  

 Yes

17/75 (22.7)

5.32

2.66–10.66

< 0.001

2.67

1.17–6.12

0.020

1/17 (5.9)

1.49

0.18–12.10

0.710

–

–

–

TB history

 No

19/286 (6.6)

Ref

     

7/154 (4.5)

Ref

     

 Yes

13/112 (11.6)

1.86

0.92–3.76

0.086

–

–

–

1/42 (2.4)

0.51

0.06–4.17

0.532

–

–

–

CD4 count (cells/mL)

  > =200

9/247 (3.6)

Ref

  

Ref

   

–

–

–

–

–

–

  < 200

20/129 (15.5)

4.54

2.06–9.97

< 0.001

3.21

1.42–7.28

0.005

 

–

–

–

–

–

–

ART

 Not initiated

6/58 (10.3)

Ref

  

Ref

   

–

–

–

–

–

–

 Initiated before study

17/184 (9.2)

0.82

0.32–2.09

0.680

0.74

0.27–2.07

0.573

 

–

–

–

–

–

–

 Initiated during study

6/132 (4.5)

0.37

0.12–1.14

0.084

0.19

0.05–0.65

0.008

 

–

–

–

–

–

–

Chest X-ray

 Normal

3/62 (4.8)

Ref

            

 Possible TB

12/164 (7.3)

1.55

0.43–5.50

0.496

–

–

–

 

–

–

–

–

–

–

 Suggestive TB

3/47 (6.4)

1.31

0.26–6.48

0.742

–

–

–

 

–

–

–

–

–

–

TB treatment

 No TB treatmenta

6/157 (3.8)

Ref

  

Ref

  

3/114 (2.6)

Ref

  

Ref

  

 Empirical treatment

11/100 (11.0)

3.04

1.12–8.21

0.029

2.51

0.79–7.90

0.115

4/31 (12.9)

4.85

1.08–21.67

0.039

4.85

1.08–21.67

0.039

 Treatment based on confirmed TB

15/141 (10.6)

2.76

1.07–7.12

0.036

1.25

0.37–4.21

0.718

1/51 (2.0)

0.77

0.08–7.41

0.822

0.77

0.08–7.41

0.822

  1. aPatients who did not receive TB treatment were all culture and/or Xpert negative