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Table 1 Antibacterial activity of erythromycin and solithromycin against S. aureus isolates as well as the resistant rates of solithromycin in each group

From: Staphylococcus aureus with an erm-mediated constitutive macrolide-lincosamide-streptogramin B resistance phenotype has reduced susceptibility to the new ketolide, solithromycin

Types (No. of isolates)

Erythromycin MICs

Solithromycin MICs

Solithromycin MICs

P values

(mg/L)

(mg/L)

(mg/L)

Range

MIC50

MIC90

Range

MIC50

MIC90

≤2

≥4

Total (236)

1‐>256

>256

>256

0.0625‐>16

2

>16

127 (53.8%)

109 (46.2%)

<0.01

 ermA (82)

1‐>256

>256

>256

0.0625‐>16

1

>16

65 (79.3%)

17 (20.7%)

 ermB (96)

1‐>256

>256

>256

0.125‐>16

8

>16

32 (33.3%)

64 (66.7%)

 ermC (58)

1‐>256

>256

>256

0.125‐>16

2

>16

30 (51.7%)

28 (48.3%)

MSSA (88)

1‐>256

>256

>256

0.0625‐>16

2

>16

48 (54.6%)

40 (45.4%)

0.86

MRSA (148)

1‐>256

>256

>256

0.0625‐>16

2

>16

79 (53.4%)

69 (46.6%)

iMLSB (66)

1‐>256

>256

>256

0.0625‐>16

0.25

>16

54 (81.8%)

12 (18.2%)

<0.01

cMLSB (170)

1‐>256

>256

>256

0.0625‐>16

4

>16

73 (42.9%)

97 (57.1%)

ERYS (30)

1‐1

1

1

0.125–0.25

0.125

0.25