Table 2 Spontaneous mutational frequencies of strains with different categories of erm and erm negative strains toward solithromycin
Types (No. of isolates tested) | Range of mutational frequencies (Median) | Hours of subculture to selection (h) | Erm+/Erm- ratioa (Frequencies) |
|---|---|---|---|
iMLSB in total | 1.3 × 10-5 to 4.2 × 10-8(2.1 × 10-6) | 40 to 88 | 59 |
 ErmA+(11) | 1.3 × 10-5 to 4.2 × 10-8 (2.7 × 10-6) | 64 to 88 | 75 |
 ErmC+(5) | 2.7 × 10-6 to 6.3 × 10-8(7.8 × 10-7) | 40 | 21 |
cMLSB in total | >3.9 × 10-4 to >4.2 × 10-5 (>1.2 × 10-4) | 40 | >3333 |
 ErmA+(5) | >3.9 × 10-4 to >8.7 × 10-5(>3.2 × 10-4) | 40 | >9048 |
 ErmB+(12) | >1.6 × 10-4 to >4.2 × 10-5(>1.2 × 10-4) | 40 | >3277 |
 Erm-(26) | 4.6 × 10-7 to <9.8 × 10-9 (3.6 × 10-8) | 40 to >88 |  |