Levels of vitamin D-associated cytokines distinguish between active and latent tuberculosis following a tuberculosis outbreak

Table 2 Performance of different analytes used to discriminate between latent and active tuberculosis

Biomarker	AUC	Sensitivity	Specificity	PPV	NPV	LR+	LR-
Plasma IL-15 < 167.6 pg/mL	0.7769	65.2%	82.6%	78.9	70.3	3.75	0.42
IL-15_nil < 137.2 pg/mL	0.9509	90.9%	88.0%	88.3	90.6	7.58	0.1
IL-15_TB < 174.2 pg/mL	0.6927	63.6%	80.0%	76.1	68.7	3.18	0.45
IL-32_nil ≥ 662.3 pg/mL	0.8109	86.4%	76.0%	78.3	84.8	3.6	0.18
IL-32_TB ≥ 627.6 pg/mL	0.9491	90.9%	92.0%	91.8	90.9	11.36	0.1
Vitamin D < 12.05 ng/mL	0.6843	39.1%	91.3%	81.8	60	4.49	0.67
IL-15_nil < 137.2 pg/mL or IL-32_TB ≥ 627.6 pg/mL	0.964	100%	82.6%	85.2	100	5.75	0

ROC curves were drawn
ROC: receiver operating characteristic; AUC: area under the curve
PPV, positive predictive value; NPV, negative predictive value; LR+, likelihood ratio-positive; LR−, likelihood ratio-negative

ISSN: 1471-2334