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Table 4 Impact of the dual therapy on analytical parameters

From: Effectiveness and safety of dual therapy with rilpivirine and boosted darunavir in treatment-experienced patients with advanced HIV infection: a preliminary 24 week analysis (RIDAR study)

 

Baseline

24 weeks

P value

CD4 lymphocytes (cells/uL)

630

667

0.071*

CD4/CD8 Ratio

0.749

0.788

0.004

Creatinine (mg/dL)

0.944

0.977

0.001

Glucose (mg/dL)

95.2

96.5

0.057

Total Cholesterol/HDL

4,13

4,10

0.107

Total Cholesterol (mg/dL)

183

196

< 0.001*

HDL-cholesterol (mg/dL)

48

52

0.005

LDL-cholesterol (mg/dL)

107

124

0.003*

Triglycerides (mg/dL)

144

157

0.172

Bilirubin (mg/dL)

0.77

0.64

0.827

GOT (U/L)

40.9

30.8

0.031

GPT (U/L)

45.9

30.3

0.011

GGT (U/L)

57.5

59.4

0.040

Alkaline Phosphatase (U/L)

98

93

0.026

Hemoglobin (g/dL)

15

14.8

0.009

Platelets (×10^3/μL)

190

189

0.346

  1. *paired samples t-test (otherwise with Wilcoxon signed-rank test)