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Table 2 Predictors of HIV-1 DNA Level at Week 48

From: The effects of antiretroviral therapy initiation time on HIV reservoir size in Chinese chronically HIV infected patients: a prospective, multi-site cohort study

 

HIV-1 DNA at week 48 (Log10 copies/106PBMCs)

Predictor

Estimate

95% CI

P Value

Univariate Model

Early ART Initiation

−0.309

− 0.408 to − 0.210

0.001

Age (years)

+ 0.007

+ 0.002 to + 0.013

0.01

Baseline HIV-1 RNA (log10 copies/mL)

+ 0.345

+ 0.268 to + 0.423

0.001

Baseline HIV-1 DNA (log10 copies /106PBMCs)

+ 0.696

+ 0.633 to + 0.759

0.001

Baseline CD4/CD8 ratio

−0.643

− 0.955 to − 0.332

0.001

Model with Early ART initiation, age, baseline HIV-1 RNA, baseline HIV-1 DNA and baseline CD4/CD8 ratio

Early ART initiation

−0.092

−0.173 to − 0.011

0.025

Age(years)

+ 0.002

−0.002 to + 0.006

0.339

Baseline HIV-1 RNA (log10 copies/mL)

+ 0.026

−0.061 to + 0.114

0.553

Baseline HIV-1DNA (log10 copies /106PBMCs)

+ 0.631

+ 0.545 to + 0.717

0.001

Baseline CD4/CD8 ratio

−0.309

−0.448 to − 0.169

0.001