Table 2 Factors associated with CD4+ and CD8+ T cells secreting IL-4 and IL-10 in the univariate and multivariate linear regression analysis
Variable | CD4+ T cells IL-4+ | CD4+ T cells IL-10+ | CD8+ T cells IL-4+ | CD8+ T cells IL-10+ | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Univariate (raw effects) | Multivariate (adjusted effects) | Univariate (raw effects) | Multivariate (adjusted effects) | Univariate (raw effects) | Multivariate (adjusted effects) | Univariate (raw effects) | Multivariate (adjusted effects) | ||||||||
B (95% CI) | P | Adjusted B (95%CI) | Adjusted P | B (95% CI) | P | Adjusted B (95%CI) | Adjusted P | B (95% CI) | P | Adjusted B (95% CI) | Adjusted P | B (95% CI) | P | Adjusted B (95% CI) | Adjusted P | |
Age (≥ 25 vs <  25 years) | 0.18(− 0.11,0.48) | 0.226 |  |  | − 0.31(− 0.87,0.24) | 0.266 |  |  | 0.05(− 0.11,0.2) | 0.559 |  |  | −0.21(− 0.48,0.05) | 0.118 |  |  |
Gender (Male vs Female) | 0.22(− 0.03,0.48) | 0.087 |  |  | 0.02(− 0.47,0.51) | 0.935 |  |  | 0.02(− 0.11,0.16) | 0.723 |  |  | −0.13(− 0.36,0.1) | 0.259 |  |  |
ALT (<  2 ULN is the reference group) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
≥ 2 & < 5 ULN | −0.21(−0.52,0.09) | 0.171 |  |  | −0.37(− 0.95,0.21) | 0.205 |  |  | −0.23(− 0.38,-0.08) | 0.004 |  |  | −0.2(− 0.47,0.08) | 0.158 |  |  |
≥ 5ULN | −0.19(− 0.6,0.22) | 0.363 |  |  | −0.27(−1.04,0.49) | 0.480 |  |  | −0.29(− 0.49,-0.09) | 0.005 |  |  | −0.18(− 0.54,0.19) | 0.339 |  |  |
Fibroscan | 0.06(−0.32,0.43) | 0.767 |  |  | −0.2(− 0.91,0.5) | 0.570 |  |  | 0.04(−0.16,0.23) | 0.714 |  |  | −0.14(− 0.47,0.2) | 0.426 |  |  |
Log HBV DNA | −0.09(− 0.15,-0.02) | 0.010 |  |  | −0.1(− 0.23,0.02) | 0.094 |  |  | −0.06(− 0.1,-0.03) | 0.000 | − 0.06(− 0.1,− 0.03) | 0.000 | -0.03(− 0.09,0.03) | 0.315 |  |  |
Log HBsAg | − 0.2(− 0.34,-0.06) | 0.005 | −0.2(− 0.34,-0.06) | 0.005 | 0.87 (0.18,1.56) | 0.014 | −0.28(− 0.54,-0.03) | 0.030 | −0.1(− 0.17,-0.03) | 0.004 |  |  | −0.09(− 0.22,0.03) | 0.153 |  |  |
HBeAg(Positive) | −0.32(− 0.58,-0.07) | 0.012 |  |  | −0.35(− 0.83,0.13) | 0.154 |  |  | −0.19(− 0.31,-0.06) | 0.005 |  |  | −0.05(− 0.28,0.19) | 0.693 |  |  |
HBeAb(Positive) | 0.29 (0.03,0.54) | 0.026 |  |  | 0.28(−0.2,0.76) | 0.244 |  |  | 0.11(−0.02,0.25) | 0.084 |  |  | 0.02(−0.21,0.25) | 0.884 |  |  |
HBsAb(Positive) | 0.18(−0.2,0.55) | 0.349 |  |  | 0.87 (0.18,1.56) | 0.014 | 0.87 (0.19,1.54) | 0.013 | −0.05(− 0.25,0.14) | 0.593 |  |  | 0.37 (0.03,0.7) | 0.032 | 0.37 (0.03,0.7) | 0.032 |
Genotype (Genotype C is the reference group) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
B | −0.18(−0.47,0.11) | 0.214 |  |  | 0.38(−0.17,0.92) | 0.174 |  |  | −0.04(− 0.19,0.11) | 0.637 |  |  | 0.23(−0.03,0.49) | 0.078 |  |  |
Other | −0.24(− 0.66,0.18) | 0.262 |  |  | 0.18(−0.6,0.97) | 0.643 |  |  | 0(−0.22,0.21) | 0.969 |  |  | 0.14(−0.23,0.52) | 0.450 |  |  |
PC mutation (Positive) | 0.17(−0.09,0.44) | 0.201 |  |  | 0.46(−0.03,0.95) | 0.068 |  |  | 0.1(−0.03,0.24) | 0.135 |  |  | 0.09(−0.15,0.33) | 0.451 |  |  |
BCP mutation (Positive) | 0.1(−0.17,0.38) | 0.455 |  |  | −0.25(− 0.76,0.26) | 0.340 |  |  | 0.09(− 0.05,0.22) | 0.230 |  |  | −0.13(− 0.37,0.11) | 0.296 |  |  |
PC and BCP mutations (Positive) | 0(−0.38,0.37) | 0.988 |  |  | −0.16(− 0.87,0.55) | 0.655 |  |  | 0.2 (0.01,0.39) | 0.037 |  |  | −0.03(− 0.37,0.31) | 0.857 |  |  |