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Table 4 Comparison of serum cytokines levels of healthy control, severe CV-A16 HFMD before and after treated with IVIG + RBV, and severe CV-A16 HFMD before and after treated with RBV only

From: Clinical characteristics and managements of severe hand, foot and mouth disease caused by enterovirus A71 and coxsackievirus A16 in Shanghai, China

Cytokine

(pg/mL)

Control (100)

M (IQR)

IVIG+RBV (19)

M (IQR)

(Before treatment)

IVIG+RBV (19)

M (IQR)

(After treatment)

RBV (125)

M (IQR)

(Before treatment)

RBV (125)

M (IQR)

(After treatment)

χ2

P

IL-1β

3.00(2.95,3.53)a

12.20(7.9199.68)b

3.15(3.00,3.55)c,a

16.80(8.79,71.00)b

3.30(3.00,3.60)c,a

126.232

< 0.001

IL-2

441.00(350.25,543.25)a

1372.50(924.50,1987.25)b

412.00(345.00,500.50)c,a

1085.50(837.50,1472.00)b

427.00(345.00,527.00)c,a

183.044

< 0.001

IL-6

4.05(3.20,4.70)a

18.20(7.44,33.30)b

4.40(3.60,4.95)c,a

11.50(5.06,90.20)b

4.20(2.78,5.30)c,a

86.937

< 0.001

IL-8

46.00(36.75,52.75)

158.00(11.80,216.00)

47.00(38.00,52.00)

63.10(21.60,571.00)

49.00(38.5,52.00)

5.638

0.228

IL-10

5.10(3.68,6.25)a

9.79(6.57,18.10)b

4.50(3.20,6.10)c,a

7.35(5.70,14.70)b

4.35(3.00,6.15)c,a

77.263

< 0.001

IFN-γ

7.00(1.60,11.00)a

47.00(38.00,51.50)b

7.50(5.00,11.50)c,a

60.20(41.00,75.40)b

8.00(5.30,12.00)c,a

15.329

0.004

TNF-α

4.65(3.75,5.40)a

25.80(16.40,41.40)b

4.20(3.70,5.20)c,a

19.05(13.90,52.18)b

4.70(3.80,5.50)c,a

192.151

< 0.001

  1. Abbreviations: IVIG intravenous gamma globulin intervention, RBV ribavirin, M median, IQR interquartile range, IL interleukin, IFN interferon, TNF tumor necrosis factor
  2. a vs b, b vs c statistical significance