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Table 1 Study characteristics

From: Diagnostic accuracy of TB-LAMP for pulmonary tuberculosis: a systematic review and meta-analysis

Study

Health system level

Microscopy type

TB culture type

MGIT contamination rate

Tests done on stored sputum

Xpert specimen type

Median Age (IQR)

Female

HIVa

Culture-positive TBb

Smear- negative TBc

Evaluation Studies

 Brazil

Reference Lab

Direct ZN ×2

2x MGIT, 2x LJ

0%

Xpert

Culture

Frozen Processed

48 (35–60)

40%

0.4%

32%

25%

 Peru

Reference Lab

Direct ZN ×2

2x MGIT, 2x LJ

1·3%

Xpert

Culture

Fresh Processed

43 (28–56)

50%

1.0%

22%

42%

 South Africa

Reference Lab

Direct ZN ×2

2x MGIT, 2x LJ

3·1%

Xpert

Culture

Fresh Processed

39 (29–47)

34%

35%

26%

51%

 Vietnam

Reference Lab

Direct ZN ×2

2x MGIT, 2x LJ

0%

Xpert

Culture

Frozen Processed

39 (26–50)

30%

2%

66%

42%

Demonstration Study

 India

Microscopy center

Direct ZN ×2

MGIT, LJ

6·5%

Culture

None

40 (27–51)

35%

2%

11%

25%

Request for Application (RFA) Studies

 India

University-affiliated DOTS clinic

Direct ZN × 1

MGIT

11·5%

Xpert

Culture

Frozen Processed

43 (29–55)

37%

2%

15%

54%3

 Vietnam

Microscopy center

Direct ZN × 2

MGIT

0%

Xpert

Culture

Fresh Processed

60 (52–70)

42%

0.5%

8%

59%

 Malawi

Microscopy center

Direct FM × 1

MGIT, LJ

8·7%

Xpert

Culture

Fresh Direct

35 (26–41)

48%

44%

16%

15%3

 Tanzania

District Hospital TB clinic

Direct FM × 2

MGIT, LJ

5·1%

Culture

Fresh Direct

37 (28–46)

45%

6%

29%

28%

 Uganda

District Hospital outpatient clinic

Direct FM ×2

2x MGIT, 2x LJ

1·3%

Culture

Fresh Direct

43 (30–54)

43%

48%

31%

45%

 Ivory Coast

District Hospital outpatient clinic

Direct ZN ×2

MGIT

6·0%

Xpert

Culture

Fresh Processed

38 (28–44)

51%

12%

33%

13%

 Madagascar

University-affiliated DOTS clinic

Direct FM ×2

2x LJ

---

Xpert

Culture

Fresh Direct

42 (29–52)

40%

---

37%

27%

Sponsored Study

 Haiti (Kaku, et al)

Urban Hospital outpatient clinic

Direct FM ×2

3x MGIT

0%

Culture

None

---

---

---

34%

23%

  1. --- information not available
  2. Abbreviations: TB tuberculosis, MGIT Mycobacterial Growth Indicator Tube, ZN Ziehl-Neelsen, FM fluorescence microscopy, LJ Lowenstein-Jensen
  3. aHIV unknown counted as negative. Reflects proportion of study population known to be HIV positive
  4. bReference standard 3 used for all studies in this calculation
  5. cSmear microscopy results based on analysis of 1 smear only