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Table 2 Serum cytokine profiles in two disease types of Mycobacterium avium complex lung disease

From: Multiplex cytokine analysis in Mycobacterium avium complex lung disease: relationship between CXCL10 and poor prognostic factors

Cytokine/GF protein (pg/mL) Radiographic Features *P-value
  min LOD max LOD FC (N = 6) NS (N = 21)  
Proinflamatory
G-CSF 16 10,000 46.6 (32.4–68.4) N/A < 0.05
GM-CSF 0.64 10,000 11.4 (1.8–50.1) 3.5 (0.64–11.7) NS
IFN-γ 3.2 10,000 12.8 (6.2–37.6) 3.9 (3.2–29.7) NS
IL-1β 0.64 10,000 3.0 (0.64–20.6) N/A NS
IL-6 0.64 2000 38.6 (18.1–225.3) 21.7 (3.8–87.6) NS
IL-7 0.64 2000 13.1 (6.3–32.5) 6.5 (0.64–9.0) NS
IL-17A 0.64 10,000 3.1 (1.2–9.0) 1.7 (0.3–15.6) NS
sCD40L 0.64 10,000 N/A 5278 (3960–6276) < 0.05
TNF-α 0.64 10,000 50.6 (19.3–131.3) 45.2 (25.6–73.5) NS
Chemokine
Eotaxin 3.2 10,000 122 (101–134) 134 (112–168) NS
GRO 16 10,000 1285 (1137–1784) 896 (771–1567) NS
IL-8 0.64 10,000 361 (143–906) 230 (104–650) NS
CXCL10 3.2 10,000 979 (757–1496) 451 (268–556) < 0.05
CCL2 3.2 10,000 600 ± 120 600 ± 183 NS
CCL3 16 2000 345 (14–610) 216 (124–505) NS
CCL4 16 10,000 191 (37–415) 173 (93–373) NS
CCL22 16 10,000 863 ± 163 657 ± 309 NS
Anti-inflammatory
IL-1RA 3.2 10,000 73.9 (31.3–136.5) 18.7 (3.2–29.4) < 0.005
IL-5 0.64 10,000 1.9 (0.64–5.9) N/A NS
IL-10 0.64 10,000 3.5 (1.4–14.7) N/A < 0.05
Growth factor
EGF 16 10,000 294 ± 66 247 ± 117 NS
FGF-2 16 10,000 94.3 (48.9–150.9) 55.0 (16.3–82.3) NS
Flt-3 L 3.2 10,000 3.2 (3.2–21.7) 12.1 (3.2–27.4) NS
TGF-α 0.64 2000 12.0 (10.3–18.9) 6.6 (4.6–13.0) NS
VEGF 80 10,000 531 ± 318 300 ± 234 NS
  1. Data are presented as mean ± standard deviation, or median (interquartile range). Items with more than half cases below or over the LOD were excluded
  2. Abbreviations, GF growth factor, LOD limit of detection, FC fibrocavitary type, NB nodular bronchiectatic type, EGF epidermal growth factor, FGF fibroblast growth factor, Flt-3 L FMS-like tyrosine kinase 3 ligand, G-CSF granulocyte colony-stimulating factor, GM-CSF granulocyte macrophage-CSF, GRO growth-related oncogene, IFN-γ interferon gamma, IL interleukin, IL-1RA IL-1 receptor antagonist, CXCL10 CXC motif ligand 10, CCL CC motif ligand, sCD40L soluble CD40 ligand, TGF transforming growth factor, TNF tumor necrosis factor, VEGF vascular endothelial growth factor, N/A not available (median was below or over LOD)
  3. *P-values were calculated in relation to two radiographic features. Student’s t-test or the Wilcoxon rank sum test was used. For enrolled cytokines/growth factors, we replaced the values less than LOD with LOD and analyzed with nonparametric analysis or Fisher’s exact test with cut-off as LOD value. NS, not significant