Table 2 Serum cytokine profiles in two disease types of Mycobacterium avium complex lung disease
Cytokine/GF protein (pg/mL) | Radiographic Features | *P-value | |||
|---|---|---|---|---|---|
|  | min LOD | max LOD | FC (N = 6) | NS (N = 21) |  |
Proinflamatory | |||||
G-CSF | 16 | 10,000 | 46.6 (32.4–68.4) | N/A | < 0.05 |
GM-CSF | 0.64 | 10,000 | 11.4 (1.8–50.1) | 3.5 (0.64–11.7) | NS |
IFN-γ | 3.2 | 10,000 | 12.8 (6.2–37.6) | 3.9 (3.2–29.7) | NS |
IL-1β | 0.64 | 10,000 | 3.0 (0.64–20.6) | N/A | NS |
IL-6 | 0.64 | 2000 | 38.6 (18.1–225.3) | 21.7 (3.8–87.6) | NS |
IL-7 | 0.64 | 2000 | 13.1 (6.3–32.5) | 6.5 (0.64–9.0) | NS |
IL-17A | 0.64 | 10,000 | 3.1 (1.2–9.0) | 1.7 (0.3–15.6) | NS |
sCD40L | 0.64 | 10,000 | N/A | 5278 (3960–6276) | < 0.05 |
TNF-α | 0.64 | 10,000 | 50.6 (19.3–131.3) | 45.2 (25.6–73.5) | NS |
Chemokine | |||||
Eotaxin | 3.2 | 10,000 | 122 (101–134) | 134 (112–168) | NS |
GRO | 16 | 10,000 | 1285 (1137–1784) | 896 (771–1567) | NS |
IL-8 | 0.64 | 10,000 | 361 (143–906) | 230 (104–650) | NS |
CXCL10 | 3.2 | 10,000 | 979 (757–1496) | 451 (268–556) | < 0.05 |
CCL2 | 3.2 | 10,000 | 600 ± 120 | 600 ± 183 | NS |
CCL3 | 16 | 2000 | 345 (14–610) | 216 (124–505) | NS |
CCL4 | 16 | 10,000 | 191 (37–415) | 173 (93–373) | NS |
CCL22 | 16 | 10,000 | 863 ± 163 | 657 ± 309 | NS |
Anti-inflammatory | |||||
IL-1RA | 3.2 | 10,000 | 73.9 (31.3–136.5) | 18.7 (3.2–29.4) | < 0.005 |
IL-5 | 0.64 | 10,000 | 1.9 (0.64–5.9) | N/A | NS |
IL-10 | 0.64 | 10,000 | 3.5 (1.4–14.7) | N/A | < 0.05 |
Growth factor | |||||
EGF | 16 | 10,000 | 294 ± 66 | 247 ± 117 | NS |
FGF-2 | 16 | 10,000 | 94.3 (48.9–150.9) | 55.0 (16.3–82.3) | NS |
Flt-3 L | 3.2 | 10,000 | 3.2 (3.2–21.7) | 12.1 (3.2–27.4) | NS |
TGF-α | 0.64 | 2000 | 12.0 (10.3–18.9) | 6.6 (4.6–13.0) | NS |
VEGF | 80 | 10,000 | 531 ± 318 | 300 ± 234 | NS |