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Table 3 Multivariate Logistic Regression Analysis of Statistically Significant Risk Factors for Invasive Fungal Diseases among Haematological Malignancy Patients Twelve-Months from Induction Chemotherapy, 2005 - 2016

From: A population-based analysis of invasive fungal disease in haematology-oncology patients using data linkage of state-wide registries and administrative databases: 2005 - 2016

Covariate

Odds ratio (OR)

Coefficient

95% confidence interval OR

p-value

Acute renal failure

1.895

0.639

1.284 – 2.798

< 0.001

 Age (ten years) a

  25 – 34

1.030

0.029

0.555 – 1.910

0.926

  35 – 44

0.996

-0.004

0.554 – 1.790

0.988

  45 – 54

1.537

0.430

0.916 – 2.580

0.103

  55 – 64

1.345

0.296

0.813 – 2.225

0.249

  65 – 74

1.134

0.126

0.690 – 1.864

0.619

  75 – 84

0.805

-0.217

0.482 – 1.344

0.406

  85 – 94

0.355

-1.037

0.186 – 0.678

0.002

  95 +

0.339

-1.083

0.045 – 2.575

0.295

Clostridium difficile infection

2.792

1.027

1.203 – 6.480

0.017

 Haematological malignancy a

  ALL

11.400

2.434

5.215 – 24.918

< 0.001

  AML

8.743

2.168

4.247 – 17.998

< 0.001

  CLL

1.734

0.550

0.793 – 3.790

0.168

  HL

0.806

-0.216

0.326 – 1.991

0.640

  MDS

1.194

0.177

0.133 – 10.708

0.874

  NHL

1.503

0.408

0.728 – 3.103

0.270

  MM

1.221

0.199

0.570 – 2.614

0.608

Haemodialysis

3.220

1.169

1.380 – 7.510

0.007

Admission to a rural hospital a

0.508

-0.676

0.368 – 0.702

< 0.001

Intensive care unit admission

1.626

0.486

1.324 – 1.997

< 0.001

Neutropenia

2.176

0.778

1.703 – 2.781

< 0.001

 Region of residence a

  Metropolitan Victoria

0.762

-0.271

0.596 – 0.976

0.031

  Interstate

0.482

-0.730

0.273 – 0.851

0.012

  Unknown

0.941

-0.061

0.278 – 3.181

0.922

Viral infection

3.117

1.137

1.081 – 8.987

0.035

CONSTANT

0.015

-4.175

-5.146 – -3.204

< 0.001

  1. aReference categories for polychotomous independent variables: Age (ten years), 15 – 24; haematological malignancy, CML; hospital region, metropolitan hospital; region of residence, rural Victoria. Reference categories were chosen as the lowest risk-burden for invasive fungal disease
  2. Abbreviations: ALL acute lymphoblastic leukaemia, AML acute myeloblastic leukaemia, CLL chronic lymphoblastic leukaemia, HL Hodgkin-lymphoma, MDS myelodysplastic syndrome, MM multiple myeloma, NHL non-Hodgkin lymphoma, OR odds ratio