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Table 1 Clinical characteristics and outcomes comparison in early and late detection groups

From: Time to positivity of blood culture is a risk factor for clinical outcomes in Staphylococcus aureus bacteremia children: a retrospective study

Variables

Early Detection Group (n = 14)

Late Detection Group

(n = 70)

P

Demographic characteristics

 Age, Median (IQR)

75.00 (16.25–143.50)

49.50 (8.49–124.75)

0.275

 Weight, Median (IQR)

23.00 (8.50–36.25)

14.50 (7.50–32.75)

0.506

 Male (n, %)

11 (78.6%)

44 (62.86%)

0.262

Underlying Conditions

 Hematologic malignancy (n, %)

2 (14.3%)

8 (11.43%)

0.765

 Congenital heart disease (n, %)

4 (28.6%)

10 (14.29%)

0.193

 Neutropenia (n, %)

2 (14.3%)

8 (11.43%)

0.765

 Primary immunodeficiency (n, %)

2 (14.3%)

5 (7.14%)

0.394

 Chronic kidney disease (n, %)

1 (7.1%)

2 (2.86%)

0.433

Source of infection

 Multiple sitesb

5 (35.7%)

19 (27.1%)

0.519

 Pneumonia

3 (21.4%)

20 (28.6%)

0.587

 Bone or joint

0 (0.0%)

13 (18.6%)

0.081

 Skin or soft tissue

0 (0.0%)

9 (12.9%)

0.158

 Primary bacteremia

0 (0.0%)

4 (5.7%)

0.362

 Intravenous catheter

2 (14.3%)

2 (2.9%)

0.068

 Catheter related infectionc

1 (7.1%)

1 (1.4%)

0.203

 Incision

0 (0.0%)

2 (2.9%)

0.525

 Endocarditis

2 (14.3%)

0 (0.0%)

0.001 a

 CNS infection

1 (7.1%)

0 (0.0%)

0.025 a

APACHE II score ≥ 15 (n, %)

5 (35.7%)

22 (31.4%)

0.755

Prior antibiotic exposure (n, %)

7 (50.0%)

28 (40.0%)

0.491

 Appropriate antibiotic exposure (n, %)

1 (7.1%)

12 (17.1%)

0.348

Immunosuppressants use (n, %)

6 (42.9%)

14 (20.0%)

0.068

Nosocomial infection (n, %)

3 (21.4%)

11 (15.7%)

0.603

Methicillin-resistance (n, %)

4 (28.6%)

25 (35.7%)

0.610

Hypoalbuminemia (n, %)

1 ((7.1%)

5 (7.1%)

1.000

Need for Treatments

 Invasive Mechanical ventilation (n, %)

6 (42.9%)

12 (17.1%)

0.033 a

 Vasoactive agent (n, %)

7 (50.0%)

13 (18.6%)

0.012 a

Outcomes

 In-hospital mortality (n, %)

8 (57.1%)

5 (7.1%)

0.000 a

 Septic shock (n, %)

8 (57.1%)

13 (18.6%)

0.002 a

 Length of hospitalization

Median (IQR)

17.00 (2.75–33.00)

22.50 (14.75–37.00)

0.151

  1. ashowed difference in the early and late detection groups (P < 0.05)
  2. b8 cases were bone or joint + skin or soft tissue, 5 cases were bone or joint + skin or soft tissue + pneumonia, 4 cases were skin or soft tissue + pneumonia, 5 cases were bone or joint + pneumonia, 2 cases were endocarditis + pneumonia
  3. cincluding urethral catheters and thoracic drain tube