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Table 1 Socioeconomic and obstetric characteristics of the OCV recipients and placebo recipients among pregnant women

From: Safety of a bivalent, killed, whole-cell oral cholera vaccine in pregnant women in Bangladesh: evidence from a randomized placebo-controlled trial

Characteristics

Pregnant during vaccination (Cohort 1)

Pregnant after vaccination (Cohort 2)

OCV recipients (nā€‰=ā€‰231)

Placebo recipients (nā€‰=ā€‰234)

p-value

OCV recipients (nā€‰=ā€‰277)

Placebo recipients (nā€‰=ā€‰299)

p-value

Median gestational age at screening visit/recruitmentā€“ (IQR; weeks)

22 (19, 25)

21 (19, 25.5)

0.541

12 (9, 15)

12 (9, 16)

0.751

Median gestational age at vaccination ā€“ (IQR; weeks)

4 (1.79, 7.71)

4.43 (2.14, 8.57)

0.407

ā€“

ā€“

ā€“

Median time of vaccination prior to pregnancy -(IQR; weeks)

ā€“

ā€“

ā€“

4.71 (2.14, 8.14)

5 (2.43, 8.29)

0.408

Exposed to the OCV in the 1st trimesterā€“ no. (%)

198 (85.71)

194 (82.91)

0.481

Ā Ā Ā 

Mean age (SD; year)

26.27 (5.70)

26.19 (5.70)

0.876

24.92 (5.10)

24.81 (5.26)

0.785

Illiterateā€“ no. (%)

53 (22.94)

49 (20.94)

0.682

39 (14.08)

54 (18.06)

0.236

Diarrhoea within past 6ā€‰months prior to baseline census-- no. (%)

24 (10.39)

28 (11.97)

0.695

31 (11.19)

16 (5.35)

0.016

Live in own house ā€“ no. (%)

37 (16.02)

34 (14.53)

0.751

59 (21.30)

62 (20.74)

0.949

Live in a household with family size ā‰¤4 ā€“ no. (%)

112 (48.48)

108 (46.15)

0.681

112 (40.43)

106 (35.45)

0.252

Live in a household using own tap as the source of drinking water-ā€“ no. (%)

15 (6.49)

13 (5.56)

0.818

18 (6.50)

31 (10.37)

0.130

Live in a household with treated drinking water-ā€“ no. (%)

127 (54.98)

133 (56.84)

0.756

177 (64.13)

189 (63.21)

0.887

Live in a household using sanitary toiletā€“ no. (%)

156 (67.53)

167 (71.37)

0.425

214 (77.26)

219 (73.24)

0.309

Median time living in the household (IQR; months)

20 (7, 48)

15 (6, 38.5)

0.369

24 (10, 48)

24 (6, 48)

0.683

Live in a household with concrete roof ā€“ no. (%)

37 (16.02)

31 (13.25)

0.475

48 (17.33)

70 (23.41)

0.088

Live in a household with concrete wall ā€“ no. (%)

161 (69.70)

160 (68.38)

0.835

205 (74.01)

212 (70.90)

0.460

Live in a household using shared kitchenā€“ no. (%)

197 (85.28)

202 (86.32)

0.850

232 (83.75)

253 (84.62)

0.866

Live in a household using shared toiletā€“ no. (%)

206 (89.18)

216 (92.31)

0.315

242 (87.36)

258 (86.29)

0.796

Live in a household with only one roomā€“ no. (%)

54 (23.38)

54 (23.08)

1.000

82 (29.60)

77 (25.75)

0.347

Obstetric history

ā€ƒHad any ANC visitaā€“ no. (%)

191 (82.68)

189 (80.77)

0.679

246 (88.81)

267 (89.30)

0.957

ā€ƒHad ankle swellingā€“ no. (%)

11 (4.76)

18 (7.69)

0.265

15 (5.42)

18 (6.02)

0.894

ā€ƒHad gestational diabetesbā€“ no. (%)

4 (1.73)

2 (0.85)

0.448

1 (0.36)

4 (1.34)

0.375

ā€ƒHad gestational hypertensioncā€“ no. (%)

1 (0.43)

4 (1.71)

0.372

4 (1.44)

8 (2.68)

0.387

ā€ƒHad eclampsia`dā€“ no. (%)

1 (0.43)

0 (0.00)

0.497

3 (1.08)

1 (0.33)

0.356

ā€ƒHad history of stresseā€“ no. (%)

26 (11.26)

23 (9.83)

0.726

29 (10.47)

38 (12.71)

0.479

ā€ƒHad previous bad obstetrical historyfā€“ no. (%)

78 (33.77)

76 (32.48)

0.844

102 (36.82)

115 (38.46)

0.749

ā€ƒHad any chronic disease7ā€“ no. (%)

9 (3.90)

6 (2.56)

0.582

11 (3.97)

12 (4.01)

1.000

ā€ƒMid-upper arm circumferenceā€‰ā‰¤ā€‰21.5ā€‰cmā€“ no. (%)

11 (6.36)

11 (6.79)

1.000

11 (4.76)

13 (5.20)

0.991

  1. aAntenatal care is the routine health control of presumed healthy prengant women without symptoms (screening) to diagnose diseases or complicating obstetric conditions without symptoms and to provide information about lifestyle, pregnancy and delivery
  2. bGestational diabetes is a high blood sugar that develops during pregnancy and usually disappears after giving birth
  3. cGestational hypertension is new hypertension presenting after 20ā€‰weeks without significant proteinuria
  4. dA convulsive state; especially: an attack of convulsions during pregnancy or childbirth
  5. eIn a medical or biological context, stress is a physical, mental, or emotional factor that causes bodily or mental tension
  6. fThe term ā€˜Bad Obstetric History or BOHā€™ is applied to mothers in whom a previous poor pregnancy outcome is likely to have a bearing on the prognosis of her present pregnancy
  7. 7The term chronic disease applies to a group of diseases that tend to be long lasting and have persistent effects