Table 2 Key molecular markers of the A/Environment/Fujian/85144/2014 (H1N8) virus
Function | Amino- Acid Mutation | Molecular characteristics of A/Environment/Fujian/85144/2014(H1N8) |
|---|---|---|
HA | ||
 HA cleavage |  | PSVQSR/GLF |
 Human receptor binding(H3 numbering) [14] | Q226L | Q |
G228S | G | |
NA | ||
 Resistant to oseltamivir or zanamivir (N2 numbering) [15] | R292K | R |
H274Y | H | |
E119V | E | |
R152K | R | |
PB2 | ||
 Increased virulence in mice [16] | E627K | E |
 Enhances pathogenicity in mice [16] | D701N | D |
M1 | ||
 Increased virulence in mice [17] | N30D | D |
T215A | A | |
M2 | ||
 Resist to amantadine | S31 N | S |
NS1 | ||
 Increased virulence in mice [18] | P42S | A |