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Table 3 MIC distribution of eravacycline and relevant antibiotics against K. pneumoniae of different resistance characteristics

From: In vitro activities of Eravacycline against 336 isolates collected from 2012 to 2016 from 11 teaching hospitals in China

Antibiotics

Sensitive, n=10

ESBL, n=10

kpc-2 positive, n=9

NDM-1 positive, n=3

mcr-1 positive, n=4

Tigecycline resistant, n=13

MIC50

MIC90

Range

MIC50

MIC90

Range

MIC50

MIC90

Range

MIC50

MIC90

Range

MIC50

MIC90

Range

MIC50

MIC90

Range

Eravacycline

0.25

0.5

0.125-0.5

0.5

1

0.125-2

0.5

2

0.25-4

0.5

1

0.5-1

1

16

0.5-16

8

16

2-16

Tigecycline

0.5

1

0.5-2

1

4

0.5-4

1

4

0.125

1

2

1--2

16

16

2-16

8

16

8-16

Piperacillin/Tazobactam

2

4

2-4

4

256

2-256

256

256

256-256

256

256

256-256

4

4

4-4

16

32

4-32

Cefoxitin

4

8

2-16

8

16

2-32

256

256

64-256

256

256

256-256

8

8

2-8

32

64

8-128

Ceftazidime

0.125

0.25

0.125-0.25

64

256

16-256

64

256

32-256

256

256

256-256

1

1

0.125-1

1

64

0.5-64

Cefoperazone/Sulbactam

0.25

0.25

0.125-0.25

16

64

8-64

256

256

256-256

256

256

256-256

1

1

0.5-1

2

32

1-128

Ceftriaxone

0.064

0.064

0.032-0.125

256

256

64-256

256

256

16-256

256

256

256-256

0.064

0.125

0.032-0.125

0.25

256

0.064-256

Cefotaxime

0.032

0.125

0.032-0.125

256

256

64-256

256

256

32-256

256

256

256-256

0.125

0.125

0.032-0.125

0.5

128

0.125-256

Cefepime

0.032

0.064

0.032-0.064

32

64

4-128

64

256

32-256

128

256

128-256

2

2

0.032-2

2

64

0.125-64

Ertapenem

0.016

0.016

0.016-0.016

0.25

0.5

0.032-0.5

32

32

32-32

32

32

32-32

0.016

0.016

0.016-0.016

0.032

0.25

0.016-0.5

Imipenem

0.125

0.25

0.125-1

0.125

0.25

0.125-0.25

8

32

8-32

8

32

8-32

0.125

0.25

0.125-0.25

0.125

0.125

0.125-0.5

Meropenem

0.016

0.032

0.016-0.032

0.032

0.064

0.032-0.125

16

32

8-32

16

32

8-32

0.032

0.064

0.032-0.064

0.032

0.064

0.016-0.064

Colistin

0.25

0.25

0.125-0.25

0.25

0.25

0.125-0.25

0.25

0.25

0.125-0.25

0.25

0.25

0.125-0.25

32

64

16-64

0.25

32

0.125-32

Amikacin

1

1

0.5-1

1

4

0.5-32

1

256

0.5-256

2

2

1--2

1

1

1-1

1

2

0.5-256

Minocycline

2

4

2-8

16

32

2-32

32

32

4-32

32

32

4-32

16

32

16-32

32

128

16-256

Ciprofloxacin

0.016

0.032

0.016-0.25

2

64

0.016-64

32

64

16-64

64

64

64-64

32

32

0.032-32

32

64

0.25-64

Levofloxacin

0.064

0.125

0.064-0.5

2

16

0.064-64

16

64

16-64

32

32

16-32

16

16

0.064-16

8

32

0.5-64

  1. a: Sensitive strains referred to strains do not have ESBL, carbapenem resistance and polymyxin resistance