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Table 1 Clinical, histological and pathological characteristics of 52 normal healthy controls, 78 patients with CHB and 73 patients with HBV-related cirrhosis

From: Potential circulating biomarkers of circulating chemokines CCL5, MIP-1β and HA as for early detection of cirrhosis related to chronic HBV (hepatitis B virus) infection

 

NHC

CHB

HBV-related cirrhosis

P value

Male

38 (73.1%)

60 (76.9%)

55 (75.3%)

ns

Female

14 (26.9%)

18 (23.1%)

18 (24.7%)

ns

Age (year)

41.3 ± 10.05

36.0 ± 9.69

47.8 ± 11.6***

< 0.001

family HBV-infection history

no

12/78

11/73

ns

duration of HBsAg positive (year)

no

7.6 ± 7.5

11.2 ± 9.1*

< 0.05

ALT(U/L)

25.2 ± 6.35

277.3 ± 229.6###

166.3 ± 397.0###***

< 0.001

AST(U/L)

18.5 ± 3.44

106.2 ± 91.9###

110.37 ± 220.1###

< 0.001

TBIL(umol/L)

13.4 ± 4.61

48.62 ± 113.12###

43.11 ± 85.50###*

< 0.001

ALB(g/L)

45.3 ± 9.62

44.6 ± 5.33

37.6 ± 3.85#*

< 0.05

PT(s)

12.68 ± 0.68

13.73 ± 1.39

17.25 ± 7.46##**

< 0.01

HBV DNA (log10 IU/ml, Mean ± SEM)

no

5.870 ± 0.194

4.242 ± 0.336***

< 0.001

HA(ng/mL)

89.2 ± 26.05

112.3 ± 133.92

228.3 ± 262.9##**

< 0.01

LN(ng/mL)

88.6 ± 28.32

77.7 ± 28.68

98.89 ± 58.97

ns

PC-III(ng/mL)

76.7 ± 33.56

78.2 ± 55.49

102.9 ± 86.07

ns

C-IV(ng/mL)

84.08 ± 21.81

107.19 ± 112.62

120.73 ± 82.93

ns

  1. ns no significance,#: vs NHC P < 0.05, ##: vs NHC P < 0.01, ###: vs NHC P < 0.001, *: vs CHB P < 0.05, **: vs CHB P < 0.01, ***: vs CHB P < 0.001