From: Utility of oral fluid samples for hepatitis B antibody detection in real life conditions
Profile | TP | FN | TN | FP | Sensitivity% (CI%) | Specificity% (CI%) | PPV% (CI%) | NPV% (CI %) | k (CI) |
---|---|---|---|---|---|---|---|---|---|
GI) Ambulatory population (291) | 72 | 30 | 178 | 11 | 70.6 (60.7–79.2) | 94.2 (89.8–97.1) | 86.7 (77.5–93.2) | 85.6 (80.0–90.0) | 67.7 (58.5–76.8) |
G2) Various Brazilian regions (1005) | 39 | 70 | 864 | 32 | 30.0 (21.2–39.9) | 96.4 (95.0–97.5) | 48.4 (37.3–59.6) | 92.5 (91.6–93.3) | 31.8 (19.2–44.3) |
MidWest region subgroup (228) | 8 | 29 | 190 | 1 | 21.6 (9.8–38.2) | 99.5 (97.1–99.9) | 88.9 (51.7–99.7) | 86.8 (81.5–90.9) | 30.4 (7.1–53.6) |
North region subgroup (336) | 17 | 31 | 279 | 9 | 35.4 (22.2–50.5) | 96.9 (94.1–98.7) | 65.4 (44.3–82.8) | 90.0 (86.1–93.1) | 39.9 (22.4–57.4) |
Southeast region subgroup (441) | 14 | 10 | 395 | 22 | 58.3 (36.6–77.9) | 94.7 (92.1–96.7) | 38.9 (27.2–51.9) | 97.5 (96.1–98.4) | 42.9 (23.9–61.9) |
Active infection (57) | 51 | 4 | 1 | 1 | 93.1 (83.3–98.1) | 50.0 (1.26–98.7) | 98.2 (93.1–99.5) | 20.0 (4.46–57.2) | 25.0 (0–87.9) |
Anti-HBc isolate (37) | 16 | 21 | – | – | 43.2 (27.1–60.5) | – | – | – | – |
Previous HBV exposure (119) | 44 | 75 | – | – | 36.9 (28.3–46.3) | – | – | – | – |
Vaccinated HBV individuals (347) | – | – | 328 | 19 | – | 94.5 (91.6–96.7) | – | – | – |
Susceptible individuals (736) | – | – | 713 | 23 | – | 96.9 (95.3–98.0) | – | – | – |
All Individuals (1296) | 111 | 100 | 1042 | 43 | 52.6 (45.6–59.5) | 96.0 (94.7–97.1) | 72.1 (64.3–79.0) | 91.2 (89.4–92.8) | 54.6 (47.6–61.6) |