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Table 1 Candidate genes tested and their relevance in DENV control

From: Using genetic variation in Aedes aegypti to identify candidate anti-dengue virus genes

Accession number

Gene name

Transcriptomic study

Function

Tissue

Direction

Differentially expressed

Interfamily variation

AAEL001022

smp-30/regucalcin

[12, 21]

Ca2+ binding domain

Whole

Down

Yes

-

AAEL001156

CG5280

[12, 13]

-

Whole

Up

No

Yes

AAEL001392

defA-assoc

[11,12,13, 20]

Immunity

Whole, Carcass

Down/Up

Yes

-

AAEL002413

sphingomyelin

[12]

Cellular membrane

Whole

Down

Yes

-

AAEL002585

CLIPA11

[12, 42]

Serine protease

Whole, MG

Down

No

Yes

AAEL003619

-

[12, 21]

Na/Cl transporter

Whole

Down

Yes

-

AAEL003787

Nopo

[12]

Zinc finger

Whole

Up

Yes

-

AAEL004361

alpha-glucosidase

[12]

Glycolysis

Whole

Down

Yes

-

AAEL004861

degringolade

[12, 13]

Peroxisomal integral protein

Whole, Carcass

Up

No

Yes

AAEL005064

CLIPB5

[12, 21]

Serine protease

Whole

Down

No

Yes

AAEL005527

Nbr/mut-7

[12, 13, 21]

miRNA maturation

Whole, SG

Down

No

Yes

AAEL006995

CG9657

[12, 21]

-

Whole

Down

No

No

AAEL007495

phosphoglycerate mutase

[12, 13, 21]

Glycolysis

Whole, Carcass, MG

Down

No

No

AAEL007845

Rab5

-

Receptor

-

-

Yes

-

AAEL008013

Obp83b

[12, 21]

Odorant

Whole

Down

No

Yes

AAEL008108

GB76c

[12, 13, 21]

Transmembrane signalling

Whole, Carcass, SG

Down

Yes

-

AAEL009317

Rab11

[12]

GTPase, cellular trafficking

Whole

Up

No

No

AAEL009602

Gdap1

[11, 12, 21]

Mitochondrial membrane

Whole, Midgut

Down

No

No

AAEL009770

SUMOE2

[12]

Sumoylation

Whole

Up

Yes

-

AAEL011375

trypsin

[12, 13, 21]

Serine protease

Whole, Carcass

Down

Yes

-

AAEL011566

-

[11, 12, 21]

Adhesion

Whole, Carcass, MG

Down

Yes

-

AAEL011817

rent1

[12]

mRNA decay

Whole

Down

No

Yes

AAEL012089

xport-A

[11, 12, 21]

Phototransduction

Whole, Carcass

Down

No

No

AAEL013712

Trypsin 5G1 precursor

[11, 12, 21]

Serine protease

Whole, Carcass

Up

No

No

AAEL014108

aquaporin

[12, 13, 21]

H2O Transporter

Whole, Carcass

Down

Yes

-

  1. Accession numbers, gene names, function and patterns of expression across families with high and low DENV loads for the tested genes. All had been previously reported in transcriptomic studies associated with differences in expression in at least two conditions (tissues/timepoints). Tissues of previous reported expression differences are shown. In “Tissue”, MG and SG correspond to midgut and salivary glands, respectively. Whether the genes were up or downregulated in those studies can be seen in “Direction”, and our reported expression patterns are shown in the column “Differentially expressed” as well as “Interfamily Variation”