Table 2 Differentially expressed genes relevant for DENV control
From: Using genetic variation in Aedes aegypti to identify candidate anti-dengue virus genes
Accession number | Gene name | Function | Direction of regulation |
|---|---|---|---|
AAEL001022 | smp-30/regucalcin | Senescence marker protein, Ca2+ binding domain | Down |
AAEL001392 | defensin A-assoc | Immunity (TOLL, Imd) | Down/Up |
AAEL002413 | sphingomyelin | Component of cellular membranes, reshuffling of which is important for virus intake | Down |
AAEL003619 | – | Putative Na/Cl transporter | Down |
AAEL003787 | Nopo | Zinc finger, ubiquitination | Up |
AAEL004361 | alpha-glucosidase | Molecule that mediates glycolysis, essential for virus replication | Down |
AAEL007845 | Rab5 | Involved in endocytic trafficking of DENV | – |
AAEL008108 | GB76c | Transmembrane signalling molecule, GTPase activity | Down |
AAEL009770 | SUMOE2 | Involved in sumoylation, process that stabilizes NS5 for replication | Up |
AAEL011375 | trypsin | Serine protease; effects of this kind of proteins are well described in the midgut | Down |
AAEL011566 | – | Putative adhesion molecule | Down |
AAEL014108 | aquaporin | Water transporter | Down |