Prevalence of tuberculosis, multidrug resistant tuberculosis and associated risk factors among smear negative presumptive pulmonary tuberculosis patients in Addis Ababa, Ethiopia

Table 7 Genotypic and phenotypic drug susceptibility testing pattern of SNPT isolates, August 01, 2017- January 05, 2018

Drug susceptibility testing	Drugs		Status (Resistant/Sensitive)
Drug susceptibility testing	Drugs		Resistant No. (%)	Sensitive No. (%)
Genotype MTBDRplus Ver. 2	Rif		03 (11.54)	23 (88.46)
	INH		07 (26.9)	19 (73.1)
	MDR TB		03 (11.54)	23 (88.46)
	Drugs	Final drug concentration tested	Drug status (Sensitive/ Resistant)
	Drugs	Final drug concentration tested	Resistant No. (%)	Sensitive No. (%)
First line MGIT DST	STR	1.0 μg/ml	03 (15%)	17 (85%)
	INH	0.1 μg/ml	03 (15%)	17 (85)
	RIF	1.0 μg/ml	02 (10%)	18 (90%)
	ETM	5.0 μg/ml	01 (5%)	19 (95%)
	MDR TB		02 (10%)	18 (90)

First Line MGIT DST; the reason for variation with LPA is that 06 isolates from which 1 MDR Isolate, 03 were INH resistant by LPA was not finalized
Operationalized definitions
1. Smear Negative Pulmonary Tuberculosis (SNPT):- Is PTB that was initially negative for two (spot-spot) consecutive sputum smear examinations and later diagnosed positive by other advanced TB diagnostic tools [11]
2. Smear Negative Presumptive Pulmonary Tuberculosis (SNPPT) patients: - Are patients who have signs and symptoms and are presumptive to be diagnosed with pulmonary tuberculosis but two of their consecutive sputum samples are microscopically negative [37]
3. Alcohol consumption: is when a person takes alcohol every day and who was taking alcohol previously, but he/ she stopped drinking now
4. Smokers: are persons who smokes cigarettes every day and who was smoking previously, but he/ she stopped now
5. Contact with TB patient: according to WHO, these are people who have close contact with infectious TB and have high risk for infection with TB

ISSN: 1471-2334