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Table 4 Subgroup analysis of N = 247 children with acute respiratory tract infection due to RSV-A ON1, stratified by setting and the first ON1 seasons (‘early’, 2011/12 to 2012/13) vs. later ON1 seasons (‘late’, 2013/14 to 2016/17); Bavaria (Germany), 2011/12–2016/17

From: Spread and clinical severity of respiratory syncytial virus A genotype ON1 in Germany, 2011–2017

 

Pediatric practice (PP)

Pediatric ward (PW)

Pediatric intensive care unit (PICU)

Early ON1

Late ON1

p

Early ON1

Late ON1

p

Early ON1

Late ON1

p

N = 40 (100)

N = 20 (100)

 

N = 67 (100)

N = 71 (100)

N = 30 (100)

N = 19 (100)

Female sex

22 (55.0)

6 (30.0)

0.10

27 (40.3)

28 (37.4)

1.00

16 (53.3)

4 (21.1)

0.04

Age, years

2.6 (1.8; 3.9)

2.5 (2.1; 3.6)

0.84

1.1 (0.5; 2.2)

1.1 (0.5; 2.3)

0.87

0.2 (0.1; 1.0)

0.5 (0.2; 1.7)

0.19

Age, month

2.3 (1.5; 12.8)

5.8 (2.1; 20.0)

0.19

Premature birth

1 (2.5)

2 (10.0)

0.26

7 (10.4)

10 (14.1)

0.61

11 (36.7)

6 (31.6)

0.77

Other preexisting condition

6 (15.0)

0 (0)

0.17

19 (28.4)

33 (46.5)

0.04

6 (20.0)

7 (36.8)

0.32

Viral coinfection

20 (50.0)

9 (45.0)

0.78

23 (34.3)

23 (32.4)

0.86

15 (50.0)

7 (36.8)

0.40

Considered severe

1 (2.5)

0 (0)

1.00

Considered life threatening

4 (13.3)

3 (21.4)

0.66

Cough

32 (80.0)

16 (80.0)

1.00

52 (77.6)

55 (77.5)

1.00

27 (90.0)

14 (73.7)

0.23

Rhinitis

29 (72.5)

18 (90.0)

0.19

43 (64.2)

40 (56.3)

0.39

25 (83.3)

11 (57.9)

0.01

Refusal to eat / drink

4 (10.0)

1 (5.0)

0.66

38 (56.7)

27 (38.0)

0.04

15 (50.0)

10 (52.6)

1.00

Tachypnea

21 (31.3)

32 (45.1)

0.12

26 (86.7)

18 (94.7)

0.64

Fever

39 (100)

20 (100)

32 (47.8)

36 (50.7)

0.74

10 (33.3)

7 (36.8)

1.00

Fever, °C

39.7 (39.0; 40.1)

40.0 (39.1; 40.2)

0.41

38.7 (38.2; 39.2)

38.8 (38.3; 39.4)

0.35

38.8 (38.5; 39.1)

38.8 (38.1; 39.6)

0.77

Bronchitis / Bronchiolitis

19 (47.5)

7 (35.0)

0.42

37 (55.2)

31 (43.7)

0.23

22 (73.3)

15 (78.9)

0.74

Pneumonia

4 (1.0)

1 (5.0)

0.66

17 (25.4)

19 (26.8)

1.00

19 (63.3)

16 (84.2)

0.19

Sec. bac.pneumonia

0 (0)

1 (1.4)

1.00

7 (23.3)

8 (42.1)

0.21

Symptoms, days

11.0 (9.0; 14.0)

10.0 (7.0; 15.0)

0.92

Hospital stay, days

3.0 (2.0; 5.0)

3.0 (2.0; 5.0)

0.68

8.0 (6.0; 11.3)

10.0 (7.0; 14.0)

0.21

PICU stay, days

4.5 (3.0; 6.3)

5.0 (2.0; 10.0)

0.76

Oxygen

26 (38.8)

33 (46.5)

0.39

28 (93.3)

19 (100)

0.51

Oxygen, days

4.0 (3.3; 4.8)

3.0 (1.0; 5.0)

0.32

5.0 (4.0; 7.0)

8.5 (4.3; 14.3)

0.06

CPAP

0 (0)

0 (0)

15 (50.0)

5 (26.3)

0.14

CPAP, days

3.0 (2.0; 5.0)

2.0 (1.0; 2.0)

0.01

Mechanical ventilation

0 (0)

0 (0)

4 (13.3)

3 (15.8)

1.00

Mechanical ventilation, days

3.0 (1.0; −)

7.0 (6.0; −)

0.18

Well-being at discharge

67 (100)

70 (98.6)

1.00

30 (100)

18 (94.7)

0.39

Well-being 14 days past visit

33 (90.0)

17 (89.5)

1.00

  1. Data shown are number of cases (percent of N) or median (quartiles). P-values were derived using Fisher’s exact test or Mann-Whitney U-test, as appropriate. P-values in boldface indicate statistical significance