Oral candidiasis is a significant predictor of subsequent severe infections during immunosuppressive therapy in anti-neutrophil cytoplasmic antibody-associated vasculitis

Table 2 Predictors of severe infection

	Univariate model		Multivariate model
	HR (95% CI)	P value	HR (95% CI)	P value
Age (per 10 years)	1.03 (0.99–1.09)	0.134	1.05 (0.99–1.12)	0.071
Male (vs. female)	1.02 (0.41–2.53)	0.959	1.61 (0.55–4.76)	0.387
Serum albumin (per 1.0 g/dL)	0.41 (0.21–0.78)	0.007	0.45 (0.19–0.99)	0.045
Serum creatinine (per 1.0 mg/dL)	1.31 (1.02–1.63)	0.038	1.16 (0.85–1.59)	0.371
Methylprednisolone pulse therapy	2.71 (1.08–6.78)	0.033	3.59 (1.07–12.0)	0.038
Oral candidiasis	5.34 (2.13–13.4)	< 0.001	4.55 (1.73–12.0)	0.002

HR hazard ratio, CI confidence interval
Data are the HR, 95% CI, and P value from Cox proportional hazard regression analyses
Adjusted for baseline characteristics including age, sex, serum albumin level, serum creatinine level, methylprednisolone pulse therapy, and oral candidiasis

ISSN: 1471-2334