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Table 5 Multivariable analysis of predictors of first line ART treatment failure among HIV positive adult patients at St. Luke Referral hospital and Tulubolo General Hospital, 2019

From: Determinants of first line antiretroviral therapy treatment failure among adult patients on ART at central Ethiopia: un-matched case control study

Variables

 

Cases

Control

COR(95% CI)

AOR(95% CI)

P value

Sex

Male

62

97

1

1

 

Female

55

136

0.63(.40,.98)

0.65(0.37,1.14)

0.137

OI after ART started.

Yes

95

148

1

  

No

22

85

0.40(0.23,0.68)

0.56(0.28,1.09)

0.089

History of malnutrition

Yes

21

25

1

1

 

No

96

208

0.54(0.29,1.03)

0.55(0.25,1.23)

0.151

Base line opportunistic infection

Yes

92

123

3.29(1.97,5.48)

1.97(1.06,3.63)

0.030*

No

25

110

1

1

 

LFU

Yes

20

14

3.22(1.56,6.65)

3.66(1.44,9.27)

0.006*

No

97

219

1

1

 

Adherence status

Good

81

195

1

1

 

Fair

15

25

1.44(0.72,2.88)

1.48(0.64,343)

0.357

Poor

21

13

3.88(1.85,8.13)

1.70(0.70,4.12)

0.233

NNRTI ART based

EFV base

46

165

1

1

 

NVP base

71

68

3.74(2.34,5.96)

2.77(1.22,6.28)

0.014*

Duration on First line ART

< 5 yr

17

100

1

  

> = 5 yr

100

133

4.42(2.48,7.86)

3.42(1.63,7.19)

0.001*

Baseline Cd4

< 100

46

32

4.06(2.40,6.88)

2.72(1.46,5.07)

0.002*

> = 100

71

201

1

1

 

Base line ART NRTI

TDF base

49

156

1

1

 

AZ based

48

44

3.47(2.06,5.8)

1.05(0.44,2.50)

0.895

D4Tbased

20

33

1.92(1.01,3.66)

39(0.13,1.10)

0.770

ART drug toxicity

Yes

17

11

1

1

 

No

100

222

0.29(0.13,.64)

0.42(0.16,1.08)

0.072

Time lag to initiate ART after confirmed HIV positive

In the Same month

21

71

1

1

 

In 1 to 24 month

78

146

1.80(1.03,3.15)

2.14(1.06,4.34)

0.033*

After 24 month

18

16

3.80(1.65,8.73)

3.82(1.37,10.6)

0.010*

Tuberculosis co-infection (at initial)

Yes

17

12

1

1

 

No

100

221

0.31(0.14,0.69)

0.50(0.20,1.24)

0.138

1st line ART substitution

Yes

43

48

1

1

 

No

74

185

0.44(0.27,0.73

0.59(0.29,1.18)

0.136