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Table 1 Frequency distribution of genotypes/allele in the study groups

From: FcγRIIIa receptor polymorphism influences NK cell mediated ADCC activity against HIV

a. Genotype (VF variants)

526 T/G (V176F)

HIV infected

N= 63(%)

HC

N= 67(%)

HIV infected vs HC

p value

OR (95% CI)

 TT(F/F)

19 (30.16)

23 (34.33)

1.00

Reference

 TG(V/F)

36 (57.14)

34 (50.75)

0.56

0.78 (0.36–1.68)

 GG(V/V)

08 (12.70)

10 (14.93)

1.00

1.03 (0.34–3.14)

Allele (V176F)

HIV infected

N = 126(%)

HC

N = 134(%)

HIV infected vs HC

p value

OR (95% CI)

 T(F)

74 (58.73)

80 (59.70)

1.00

Reference

 G(V)

52 (41.27)

54 (40.30)

0.90

1.04 (0.63–1.71)

b. Genotype (YH variants)

428 T/C (Y158H)

HIV infected

N = 63(%)

HC

N = 67(%)

HIV infected vs HC

p value

OR (95% CI)

 TT(Y/Y)

48 (76.19)

23 (34.33)

1.00

Reference

 TC(Y/H)

15 (23.81)

44 (65.67)

< 0.0001

0.16 (0.07–0.35)

 CC(H/H)

0 (0)

0 (0)

Allele (Y158H)

HIV infected

N = 126(%)

HC

N = 134(%)

HIV infected vs HC

p value

OR (95% CI)

 T(Y)

111 (88.10)

90 (67.16)

1.00

Reference

 C(H)

15 (11.90)

44 (32.84)

< 0.0001

3.62 (1.89–6.92)

  1. a: Frequency distribution of V176F and Y158H polymorphisms in HIV infected vs HIV uninfected healthy control groups. Presence of TT (F/F) for TG (V/F), GG (V/V) genotypes, T for G allele was taken as reference group for statistical analysis
  2. b: Frequency distribution of Y158H polymorphism in HIV infected vs healthy control groups. Presence of TT (Y/Y) for TC (Y/H), CC (H/H) genotypes, T for C allele was taken as reference group for statistical analysis
  3. Fisher’s exact test was applied. N = number of subjects; (%) = frequency of genotypes/alleles, OR = Odds ratio; CI = Confidence Interval. The results with significance are shown in bold