SNP | Model | Genotype | Patients no (%) | Controls no (%) | OR (95% CI) | P-value |
---|---|---|---|---|---|---|
TNF-α (− 238 G/A) | G/G | 10 (9.3) | 13 (12.2) | 1.00 | 0.51 | |
A/G | 97 (90.7) | 94 (87.8) | 0.75 (0.31–1.78) | |||
A/A | 0 | 0 | – | |||
Allele | A | 97 (45) | 120 (56) | 0.927 (0.633–1.358) | 0.697 | |
G | 117 (55) | 94 (44) | ||||
IL-12 (+1188 A/C) | Codominant | C/C | 22 (20.6) | 29 (27.1) | 1.00 | 0.19 |
A/C | 78 (72.9) | 66 (61.7) | 0.64 (0.34–1.22) | |||
A/A | 7 (6.5) | 12 (11.2) | 1.30 (0.44–3.85) | |||
Dominant | C/C | 22 (20.6) | 29 (27.1) | 1.00 | 0.26 | |
A/C-A/A | 85 (79.4) | 78 (72.9) | 0.70 (0.37–1.31) | |||
Recessive | C/C-A/C | 100 (93.5) | 95 (88.8) | 1.00 | 0.23 | |
A/A | 7 (6.5) | 12 (11.2) | 1.80 (0.68–4.78) | |||
Overdominant | C/C-A/A | 29 (27.1) | 41 (38.3) | 1.00 | 0.08 | |
A/C | 78 (72.9) | 66 (61.7) | 0.60 (0.34–1.07) | |||
Allele | A | 126 (59) | 112 (52) | 0. 962 (0.656–1.412) | 0.845 | |
C | 88 (41) | 102 (48) | ||||
IL-13 (−1112C/T) | Codominant | T/T | 22 (20.6) | 12 (11.2) | 1.00 | 0.15 |
C/T | 80 (74.8) | 91 (85) | 2.09 (0.97–4.48) | |||
C/C | 5 (4.7) | 4 (3.7) | 1.47 (0.33–6.52) | |||
Dominant | T/T | 22 (20.6) | 12 (11.2) | 1.00 | 0.06 | |
C/T-C/C | 85 (79.4) | 95 (88.8) | 2.05 (0.96–4.39) | |||
Recessive | T/T-C/T | 102 (95.3) | 103 (96.3) | 1.00 | 0.73 | |
C/C | 5 (4.7) | 4 (3.7) | 2.05 (0.96–4.39) | |||
Overdominant | T/T-C/C | 27 (25.2) | 16 (14.9) | 1.00 | 0.059 | |
C/T | 80 (74.8) | 91 (85) | 1.92 (0.97–3.82) | |||
Allele | T | 124 (58) | 115 (54) | 1.186 (0.810–1.738) | 0.381 | |
C | 90 (42) | 99 (46) | ||||
IL-13 (−1512A/C) | Codominant | A/A | 23 (21.5) | 12 (11.2) | 1.00 | 0.094 |
A/C | 80 (74.8) | 88 (82.2) | 2.11 (0.99–4.51) | |||
C/C | 4 (3.7) | 7 (6.5) | 3.35 (0.82–13.78) | |||
Dominant | A/A | 23 (21.5) | 12 (11.2) | 1.00 | 0.041 | |
A/C-C/C | 84 (78.5) | 95 (88.8) | 2.17 (1.02–4.62) | |||
Recessive | A/A-A/C | 103 (96.3) | 100 (93.5) | 1.00 | 0.35 | |
C/C | 4 (3.7) | 7 (6.5) | 1.80 (0.51–6.35) | |||
Overdominant | A/A-C/C | 27 (25.2) | 19 (17.8) | 1.00 | 0.18 | |
A/C | 80 (74.8) | 88 (82.2) | 1.56 (0.81–3.03) | |||
Allele | A | 126 (59) | 112 (52) | 0.767 (0.523–1.124) | 0.174 | |
C | 88 (42) | 102 (48) |