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Table 2 Distribution of microorganisms isolated from specimens taken from SBA and SAA groups

From: Effect of prior receipt of antibiotics on the pathogen distribution: a retrospective observational cohort study on 27,792 patients

OrganismsNo. of Isolates in SBA Group
(N = 6516), n (%)
No. of Isolates in SAA Group
(N = 2334), n (%)
P value
Bacteria6256 (96.0%)2138 (91.6%)< 0.001
 Gram-positive organism1773 (27.2%)577 (24.7%)0.020
  S. aureus556 (8.5%)232 (9.9%)0.041
  CNS469 (7.2%)105 (4.5%)< 0.001
  Streptococcus spp.311 (4.8%)64 (2.7%)< 0.001
  Enterococcus spp.437 (6.7%)176 (7.5%)0.173
 Gram-negative organism4268 (65.5%)1515 (64.9%)0.607
  Enterobacteriaceae2777 (42.6%)847 (36.3%)< 0.001
   E. coli1008 (15.5%)226 (9.7%)< 0.001
   K. pneumoniae1037 (15.9%)375 (16.1%)0.863
   Enterobacter spp.237 (3.6%)125 (5.4%)< 0.001
   Other Enterobacteriaceae bacteria495 (7.6%)121 (5.2%)< 0.001
  Non-fermenting bacteria1296 (19.9%)647 (27.7%)< 0.001
   Pseudomonas spp.569 (8.7%)236 (10.1%)0.047
   Acinetobacter spp.487 (7.5%)274 (11.7%)< 0.001
   Burkholderia spp.32 (0.5%)17 (0.7%)0.185
   S. maltophilia114 (1.7%)61 (2.6%)0.01
  Other non-fermenting bacteria94 (1.4%)59 (2.5%)< 0.001
   H. influenzae150 (2.3%)19 (0.8%)< 0.001
   M. catarrhalis45 (0.7%)2 (0.1%)< 0.001
 Other bacteria215 (3.3%)46 (2.0%)0.001
Fungi260 (4.0%)196 (8.4%)< 0.001
Candida spp.233 (3.6%)185 (7.9%)< 0.001
Aspergillus spp.20 (0.3%)10 (0.4%)0.386
Cryptococcus spp.3 (0.0%)0 (0.0%)0.571*
 Other fungi4 (0.0%)1 (0.0%)0.854#
  1. Abbreviations: SBA specimen taken before antibiotic therapy, SAA specimen taken after antibiotic therapy, S. aureus Staphylococcus aureus, CNS coagulase-negative Staphylococcus, E. coli Escherichia coli, K. pneumoniae Klebsiella pneumoniae, S. maltophilia Stenotrophomonas maltophilia, H. influenzae Haemophilus influenzae, M. catarrhalis Moraxella catarrhalis
  2. *Fisher’s exact test
  3. # Corrected chi-square test