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Table 2 Distribution of microorganisms isolated from specimens taken from SBA and SAA groups

From: Effect of prior receipt of antibiotics on the pathogen distribution: a retrospective observational cohort study on 27,792 patients

Organisms

No. of Isolates in SBA Group

(N = 6516), n (%)

No. of Isolates in SAA Group

(N = 2334), n (%)

P value

Bacteria

6256 (96.0%)

2138 (91.6%)

< 0.001

 Gram-positive organism

1773 (27.2%)

577 (24.7%)

0.020

  S. aureus

556 (8.5%)

232 (9.9%)

0.041

  CNS

469 (7.2%)

105 (4.5%)

< 0.001

  Streptococcus spp.

311 (4.8%)

64 (2.7%)

< 0.001

  Enterococcus spp.

437 (6.7%)

176 (7.5%)

0.173

 Gram-negative organism

4268 (65.5%)

1515 (64.9%)

0.607

  Enterobacteriaceae

2777 (42.6%)

847 (36.3%)

< 0.001

   E. coli

1008 (15.5%)

226 (9.7%)

< 0.001

   K. pneumoniae

1037 (15.9%)

375 (16.1%)

0.863

   Enterobacter spp.

237 (3.6%)

125 (5.4%)

< 0.001

   Other Enterobacteriaceae bacteria

495 (7.6%)

121 (5.2%)

< 0.001

  Non-fermenting bacteria

1296 (19.9%)

647 (27.7%)

< 0.001

   Pseudomonas spp.

569 (8.7%)

236 (10.1%)

0.047

   Acinetobacter spp.

487 (7.5%)

274 (11.7%)

< 0.001

   Burkholderia spp.

32 (0.5%)

17 (0.7%)

0.185

   S. maltophilia

114 (1.7%)

61 (2.6%)

0.01

  Other non-fermenting bacteria

94 (1.4%)

59 (2.5%)

< 0.001

   H. influenzae

150 (2.3%)

19 (0.8%)

< 0.001

   M. catarrhalis

45 (0.7%)

2 (0.1%)

< 0.001

 Other bacteria

215 (3.3%)

46 (2.0%)

0.001

Fungi

260 (4.0%)

196 (8.4%)

< 0.001

 Candida spp.

233 (3.6%)

185 (7.9%)

< 0.001

 Aspergillus spp.

20 (0.3%)

10 (0.4%)

0.386

 Cryptococcus spp.

3 (0.0%)

0 (0.0%)

0.571*

 Other fungi

4 (0.0%)

1 (0.0%)

0.854#

  1. Abbreviations: SBA specimen taken before antibiotic therapy, SAA specimen taken after antibiotic therapy, S. aureus Staphylococcus aureus, CNS coagulase-negative Staphylococcus, E. coli Escherichia coli, K. pneumoniae Klebsiella pneumoniae, S. maltophilia Stenotrophomonas maltophilia, H. influenzae Haemophilus influenzae, M. catarrhalis Moraxella catarrhalis
  2. *Fisher’s exact test
  3. # Corrected chi-square test