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Table 1 Drug resistance mutations from ReSeqTB, August 2017. Sensitivity, specificity, and p-values for these mutations were calculated by ReSeqTB based on evidence from the literature

From: A retrospective genomic analysis of drug-resistant strains of M. tuberculosis in a high-burden setting, with an emphasis on comparative diagnostics and reactivation and reinfection status

DRUG

GENE

MUTATION

SENSITIVITY

SPECIFICITY

P-VALUE

RIFAMPICIN

rpoB

Q432K

0.00

1.00

0.01

rpoB

Q432P

0.00

1.00

0.01

rpoB

D435Y

0.02

1.00

0.00

rpoB

D435G

0.00

1.00

0.01

rpoB

D435V

0.07

1.00

0.00

rpoB

H445D

0.05

1.00

0.00

rpoB

H445Y

0.04

1.00

0.00

rpoB

H445R

0.02

1.00

0.00

rpoB

S450W

0.01

1.00

0.00

rpoB

S450L

0.69

1.00

0.00

rpoB

L452P

0.02

1.00

0.00

ISONIAZID

inhA

S94A

0.01

1.00

0.00

inhA-Pro

c-15t

0.15

0.99

0.00

inhA-Pro

t-8a

0.00

1.00

0.01

inhA-Pro

t-8c

0.01

1.00

0.00

katG

S315N

0.01

1.00

0.00

katG

S315T

0.70

0.99

0.00

OFLOXACIN

gyrA

G88C

0.01

1.00

0.04

gyrA

A90V

0.20

0.99

0.00

gyrA

S91P

0.07

1.00

0.00

gyrA

D94N

0.04

1.00

0.00

gyrA

D94H

0.02

1.00

0.00

gyrA

D94Y

0.06

1.00

0.00

gyrA

D94A

0.09

1.00

0.00

gyrA

D94G

0.34

0.99

0.00

KANAMYCIN

rrs

a1401g

0.57

0.99

0.00

AMIKACIN

rrs

a1401g

0.76

0.99

0.00

rrs

g1484t

0.01

1.00

0.04

CAPREOMYCIN

rrs

a1401g

0.71

0.96

0.00

rrs

g1484t

0.01

1.00

0.02

STREPTOMYCIN

rpsL

K43R

0.63

0.99

0.00

rpsL

K88R

0.05

1.00

0.00

PYRAZINAMIDE

pncA

D49G

0.02

1.00

0.00

pncA

H57D

0.07

1.00

0.00

pncA

H57R

0.01

1.00

0.01

pncA

W68R

0.02

1.00

0.00

pncA

T76P

0.03

1.00

0.02

pncA

T76P

0.01

1.00

0.03

pncA

G97D

0.01

1.00

0.00

pncA

Q10P

0.13

1.00

0.00

pncA

D12A

0.01

1.00

0.01

pncA

C14R

0.01

1.00

0.00

pncA

V139L

0.01

1.00

0.01

ETHAMBUTOL

embB

G406S

0.01

1.00

0.00

embB

G406C

0.00

1.00

0.01

embB

G406D

0.03

1.00

0.00

embB

G406A

0.02

1.00

0.00

embB

Q497R

0.10

1.00

0.00

embB

M306L

0.02

1.00

0.00

embB

M306V

0.34

0.98

0.00

embB

M306I

0.23

0.98

0.00

embB

M306I

0.05

0.99

0.00

embB

M306I

0.02

1.00

0.00