Skip to main content

Table 5 Toxicity Criteria [20]

From: A multicenter randomized placebo controlled trial of rifampin to reduce pedal amputations for osteomyelitis in veterans with diabetes (VA INTREPID)

 

Mild (Grade 1)

Moderate (Grade 2)

Severe or Medically Significant but Not Immediately Life-Threatening (Grade 3)

Life-Threatening Consequences (Grade 4)

Liver Enzymes –either ALT, AST increase by factor

>ULN-3.0 x ULN

>3.0–5.0 x ULN

>5.0–20 x ULN

> 20 x ULN

Bilirubin

>ULN-1.5 x ULN

>1.5–3.0 x ULN

>3.0–10.0 x ULN

>10 x ULN

Creatinine – mg/dL

Normal baseline

1.5 x ULN

>1.5–3.0 x ULN

>3.0–6.0 x ULN

> 6.0 x ULN

Creatinine – mg/dL

Elevated baseline

1.5 x baseline

>1.5–3.0 x baseline

>3.0–6.0 x baseline

> 6.0 x baseline

Hemoglobin gm/dL

< LLN-10.0

< 10.0 to 8.0

< 8.0

Life-threatening, urgent intervention indicated

WBC Decrease - cell/mm3

LLN- 3000

2000 – 3000

1000 – 2000

< 1000

Platelets Decreased - cell/mm3

LLN - 75,000

50,000 - < 75,000

< 50,000–25,000

< 25,000