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Table 3 In vitro antifungal susceptibility of 1844 clinical isolates of Candida species as determined by the CLSI method

From: Molecular identification and antifungal susceptibility profile of yeast from vulvovaginal candidiasis

     

Antifungal agents

   

Candida species(n)

 

BUC

CLO

FLC

ITC

MIC

TEC

VRC

C. albicans, n = 1272

Range

0.015–32

0.015–32

0.06–128

0.015–32

0.015–32

0.015–32

0.015–8

GM

0.11

0.05

0.79

0.09

0.30

0.15

0.07

MIC90

1

0.25

4

1

4

2

0.5

R

  

7.7%

10.2%

  

6.2%

C. africana, n = 49

Range

0.015–2.

0.015–4

0.125–1

0.015–1

0.015-0.5

0.03–16

0.03–0.5

GM

0.04

0.04

0.25

0.04

0.04

0.07

0.04

MIC90

0.06

0.06

0.5

0.06

0.125

0.5

0.06

C. dubliniensis n = 1

Range

0.015

0.015

4

0.125

0.03

0.015

0.015

C. glabrata, n = 267

Range

0.015–16

0.015–16

0.125–128

0.015–32

0.015–32

0.015–32

0.015–32

GM

0.21

0.20

1.48

0.38

0.25

0.16

0.09

MIC90

1

1

8

4

2

1

0.25

R

  

3.4%

29.1%

  

–

C. nivariensis, n = 9

Range

0.03–1

0.03–0.5

0.125–32

0.03–0.5

0.03–16

0.03–1

0.03–4

MIC50

0.03

0.06

2

0.5

0.03

0.03

0.06

MIC90

0.125

0.125

4

0.5

2

1

0.5

C. bracarensis, n = 2

Range

0.03–1

0.03–0.5

0.25–2

0.125–2

0.03–4

0.03–1

0.03–0.125

MIC50

0.03

0.03

0.25

0.125

0.03

0.03

0.03

MIC90

1

0.5

2

2

4

1

0.125

C. parapsilosis, n = 76

Range

0.03–4

0.015–1

0.125–4

0.03–4

0.03–4

0.015–32

0.015–2

GM

0.18

0.04

0.47

0.07

0.54

0.03

0.04

MIC90

1

0.06

1

0.25

2

0.03

0.06

R

  

0

3%

  

1%

C. metapsilosis, n = 20

Range

0.03–1

0.03–0.25

0.25–4

0.03–1

0.03–8

0.015–0.05

0.015–0.06

GM

0.16

0.04

0.79

0.08

0.48

0.04

0.03

MIC90

1

0.06

2

1

4

0.25

0.06

C. orthopsilosis, n = 6

Range

0.03–8

0.03–1

0.125–4

0.03–1

0.25–8

0.03–0.25

0.03–0.25

MIC50

0.5

0.06

1.0

0.25

1.0

0.03

0.06

MIC90

8

1

4

1

8

0.25

0.25

C. tropicalis, n = 61

Range

0.03–2

0.015–0.5

0.125–128

0.015–32

0.03–32

0.03–2

0.03–4

GM

0.15

0.05

0.66

0.07

0.70

0.08

0.05

MIC90

1

0.25

8

0.125

8

0.25

0.25

R

  

10.9%

5.6%

  

4.3%

C. krusei, n = 54

Range

0.06–16

0.015–0.5

0.25–64

0.015–4

0.03–16

0.03–4

0.03–1

GM

0.85

0.08

15.69

0.27

0.72

0.14

0.21

MIC90

4

0.5

64

1

8

1

0.5

R

  

–

12.5%

  

0

Saccharomyces cerevisiae, n = 12

Range

0.015–2

0.015–1

0.125–32

0.015–2

0.06–8

0.015–0.5

0.03–1

GM

0.1

0.09

1.2

0.20

0.54

0.11

0.09

MIC90

0.5

0.5

8

2

4

0.5

0.25

C. guilliermondii, n = 2

Range

0.06–4

0.03–4

0.5–16

0.125–16

1–16

0.03–0.25

0.06–1

MIC50

0.06

0.03

0.5

0.125

1

0.03

0.06

MIC90

4

4

16

16

16

0.25

1

R

  

0

50%

  

0

C. lusitaniae, n = 1

Range

0.03

0.03

0.125

0.03

0.03

0.03

0.03

C.Fabianii, n = 3

Range

0.03–0.25

0.03–0.06

0.5–1

0.03–0.25

0.125–1

0.03

0.03

MIC50

0.125

0.03

0.5

0.06

0.125

0.03

0.03

MIC90

0.25

0.06

1

0.25

1

0.03

0.03

Trichosporon asahii,n = 1

Range

0.03

0.03

0.25

0.03

0.06

0.03

0.03

Rhodotorula, n = 3

Range

0.03–0.5

0.03–1

4–128

0.03–8

0.25–8

0.03–0.5

0.03–1

MIC50

0.06

0.06

64

2

1

0.06

0.03

MIC90

0.5

1

128

8

8

0.5

1

Kodamaea ohmeri, n = 2

Range

0.125–0.5

0.03

0.25–2

0.125–0.25

0.25–0.5

0.03

0.03

MIC50

0.125

0.03

0.25

0.125

0.25

0.03

0.03

MIC90

0.5

0.03

2

0.25

0.5

0.03

0.03

Issatchenkia terricola,n = 2

Range

1–4

0.06–0.125

32–64

0.25–0.5

0.5

0.25

0.25

MIC50

1

0.06

32

0.25

0.5

0.25

0.25

MIC90

4

0.125

64

0.5

0.5

0.25

0.25

Torulaspora pretoriensis,n = 1

Range

0.25

0.03

8

0.5

0.5

0.125

0.125

ATCC90028a

Range

0.015–0.5

0.015–0.5

0.125–2

0.015–4

0.008–0.015

0.015–32

0.015–8

GM

0.04

0.03

0.21

0.08

0.06

0.03

0.03

MIC90

0.125

0.03

0.5

0.25

0.015

0.03

0.03

Candida species(n)

Antifungal agents

 

AmB

FLU

NYS

TEB

AFG

CFG

MFG

C. albicans n = 1272

Range

0.015–32

0.03–128

0.03–32

0.03–256

0.008–0.5

0.008–0.5

0.008–0.5

GM

0.22

0.70

1.60

45.11

0.015

0.1

0.03

MIC90

0.5

4

8

256

0.03

0.25

0.25

R

 

3.3%

  

0

0

0

C. africana n = 49

Range

0.03–32

0.06–8

0.125–4

0.25–256

0.008–0.03

0.015–0.5

0.008–0.5

GM

0.08

0.68

0.5

17.31

0.01

0.06

0.02

MIC90

1

2

4

128

0.015

0.25

0.06

C. dubliniensis n = 1

Range

0.06

0.06

0.25

16

0.008

0.015

0.008

C. glabrata n = 267

Range

0.03–2

0.06–16

0.03–32

0.25–256

0.008–0.5

0.008–0.5

0.008–0.5

GM

0.29

0.18

3.39

26.62

0.03

0.11

0.05

MIC90

1

1

8

256

0.06

0.25

0.25

R

 

0

  

0

0

0

C. nivariensis n = 9

Range

0.06–2

0.125–4

0.5–4

1–256

0.015–0.06

0.08–0.5

0.015–0.5

MIC50

0.06

0.5

1

128

0.06

0.25

0.015

MIC90

2

2

4

256

0.06

0.5

0.5

C. bracarensis n = 2

Range

0.06–1

0.125–2

0.25–8

8–256

0.015–0.03

0.125–0.5

0.015–0.5

MIC50

0.06

0.125

0.25

8

0.015

0.125

0.015

MIC90

1

2

8

256

0.03

0.5

0.5

C. parapsilosis n = 76

Range

0.03–2

0.125–8

0.03–32

0.25–256

0.008–1

0.008–1

0.008–1

GM

0.19

0.14

0.59

0.62

0.69

0.60

0.54

MIC90

1

0.125

4

32

0.5

0.5

0.5

R

 

0

  

5.2%

5.2%

1.3%

C. metapsilosis n = 20

Range

0.015–0.5

0.125–4

0.06–4

0.25–256

0.015–0.5

0.008–0.5

0.015–1

GM

0.10

0.177

0.46

2.17

0.17

0.17

0.39

MIC90

0.5

1

4

256

0.25

0.25

0.5

C. orthopsilosis n = 6

Range

0.06–0.25

0.125–2

0.06–8

0.25–128

0.008–1

0.015–1

0.008–0.5

MIC50

0.125

1

0.5

64

0.008

0.03

0.25

MIC90

0.25

2

8

128

1

1

0.5

C. tropicalis n = 61

Range

0.03–1

0.125–32

0.03–8

0.25–256

0.015–0.125

0.008–0.5

0.008–0.5

GM

0.19

0.23

0.54

60.02

0.03

0.24

0.04

MIC90

0.5

1

4

256

0.06

0.5

0.5

R

 

1.8%

  

0

0

0

C. krusei n = 54

Range

0.03–1

0.125–32

0.03–4

16–256

0.015–0.5

0.008–1

0.008–0.5

GM

0.43

4.2

0.32

75.66

0.08

0.08

0.15

MIC90

1

16

1

256

0.125

0.5

0.25

R

 

2.9%

  

0

1.85%

0

Saccharomyces cerevisiae n = 12

Range

0.03–4

0.06–8

0.125–32

0.25–256

0.015–0.5

0.008–0.5

0.015–0.5

GM

0.18

0.21

0.78

53.20

0.14

0.10

0.18

MIC90

1

1

8

256

0.5

0.25

0.25

C. guilliermondii n = 2

Range

0.06–0.5

0.125–0.25

0.25–0.5

64–128

0.015–0.25

0.25–0.5

0.015–0.25

MIC50

0.06

0.125

0.25

64

0.015

0.25

0.015

MIC90

0.5

0.25

0.5

128

0.25

0.5

0.25

R

 

0

  

0

0

0

C. lusitaniae n = 1

Range

0.125

0.125

0.25

0.25

0.03

0.25

0.015

C. fabianii n = 3

Range

0.06–0.25

0.125

0.25

128

0.015–0.03

0.015–0.25

0.015–0.06

MIC50

0.06

0.125

0.25

128

0.015

0.015

0.03

MIC90

0.25

0.125

0.25

128

0.03

0.25

0.06

Trichosporon asahii n = 1

Range

0.125

1

0.25

128

0.015

0.5

0.015

Rhodotorula n = 3

Range

0.03–0.5

0.125

0.06–0.125

8–256

0.06–0.5

0.25–0.5

0.25–0.5

MIC50

0.03

0.125

0.06

8

0.06

0.25

0.25

MIC90

0.5

0.125

0.125

256

0.5

0.5

0.5

Kodamaea ohmeri n = 2

Range

0.125–1

0.125

0.5

128

0.015

0.125–0.25

0.015–0.03

MIC50

0.125

0.125

0.5

128

0.015

0.125

0.015

MIC90

1

0.125

0.5

128

0.015

0.25

0.03

Issatchenkia terricola n = 2

Range

0.125–0.5

8

0.5

128–256

0.06

0.06

0.008

MIC50

0.125

8

0.5

128

0.06

0.06

0.008

MIC90

0.5

8

0.5

256

0.06

0.06

0.008

Torulaspora pretoriensis n = 1

Range

0.125

0.125

0.25

16

0.015

0.125

0.015

ATCC90028a

Range

0.03–2

0.125–8

0.25–16

1–256

0.008–0.015

0.015–0.5

0.008–0.015

 

GM

0.22

0.64

1.31

88.22

0.01

0.09

0.01

 

MIC90

1

2

8

256

0.015

0.5

0.015

  1. Note: GM geometry mean, BUC butoconazole, CLO Clotrimazole, FLC Fluconazole, ITC Itraconazole, VRC Voriconazole, MIC Miconazole, TEC Terconazole, AmB Amphotericin B, FLU Flucytosine, NYS Nystatin, TEB Terbinafine, AFG Anidulafungin, CFG Caspofungin, MFG Micafungin
  2. a ATCC90028 was tested 57 times
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