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Table 3 Prevalence of haplotypes of Pvcrt-o, Pvmdr1, Pvdhps and Pvdhfr in P. vivax isolates

From: Prevalence of molecular markers associated with drug resistance of Plasmodium vivax isolates in Western Yunnan Province, China

Genes

Haplotype

Codona

Number (%)

Pvdhfr

 

Wild type

I13F57S58T61H99S117I173

3 (5.17)

 

Mutant type

 

55 (94.83)

 

Mutant tandem repeat

I13F57S58T61-S117I173

10 (17.24)

 

Single mutant

I13F57S58T61S99S117I173

17 (29.31)

 

Double mutant and tandem repeat

I13F57R58T61-N117I173

12 (20.69)

 

Quadruple mutant(a)

I13I57R58M61H99T117I173

9 (15.52)

 

Quadruple mutant(b)

I13L57R58M61H99T117I173

5 (8.62)

 

Quintuple mutant

I13I57R58M61S99T117I173

2 (3.45)

Pvdhps

 

Wild type

S382A383K512A553R580V585

29 (50.00)

 

Single mutant

S382G383K512A553R580V585

20 (34.48)

 

Double mutant

S382G383K512G553R580V585

8 (13.79)

 

Quadruple mutant

C382G383E512G553R580V585

1 (1.72)

Pvmdr1

 

Wild type

T958Y976K997F1076

0

 

Single mutant

M958Y976K997F1076

9 (15.52)

 

Double mutant

M958Y976K997L1076

49 (84.48)

Pvcrt-o

 

Wild type

 

47 (81.03)

 

Mutant (“AAG” insertion)

 

11 (18.97)

  1. a:Mutant amino acids are shown in bold