Table 2 Median serum levels of selected cytokines among participants with and without TB occurrence classified by preventive treatment at T0 (Median [Q25-Q75] (pg/ml))

CTACK

317.71 (247.15, 392.20)

339.63 (288.62, 381.48)

0.817

245.16 (183.03, 342.38)

340.84 (260.21, 385.66)

0.164

Eotaxin

86.14 (56.31, 100.06)

34.46 (29.40, 37.82)

< 0.001

69.18 (58.08, 87.05)

37.14 (26.61, 66.58)

0.008

GRO-α

88.03 (74.31, 136.90)

79.17 (69.80, 84.97)

0.227

113.26 (100.91, 130.08)

69.82 (55.58, 89.86)

< 0.001

IP-10

564.61 (372.63, 670.62)

373.06 (329.38, 525.68)

0.173

514.05 (380.24, 606.51)

438.45 (351.99, 499.43)

0.275

MCP-1(MCAF)

12.60 (9.20, 16.31)

6.81 (5.14, 9.74)

0.017

14.08 (10.57, 20.05)

7.91 (5.65, 10.10)

< 0.001

MCP-3

1.15 (0.30, 1.96)

0.83 (0.42, 1.07)

0.738

1.78 (0.45, 3.59)

0.80 (0.43, 1.70)

0.354

MIF

305.23 (227.36, 405.16)

282.69 (255.65, 348.78)

0.396

318.45 (195.43, 358.95)

271.78 (220.06, 312.82)

0.322

MIG

356.29 (308.93, 590.65)

285.33 (179.67, 366.12)

0.129

371.04 (226.06, 612.31)

308.06 (214.66, 428.46)

0.430

MIP-1α

1.35 (1.17, 1.82)

1.18 (0.95, 1.35)

0.100

1.47 (1.41, 1.85)

1.32 (0.94, 1.51)

0.024

MIP-1β

48.10 (38.42, 57.29)

38.03 (33.57, 43.83)

0.048

50.75 (47.05, 63.37)

38.06 (30.83, 44.48)

< 0.001

PDGF-BB

64.30 (42.51, 198.85)

84.51 (26.05, 114.55)

0.425

146.33 (98.52, 232.85)

43.91 (26.70, 71.55)

0.001

RANTES

1314.40 (677.29, 1607.11)

1134.09 (467.87, 1437.52)

0.488

1194.57 (839.53, 2194.69)

762.83 (468.35, 1217.44)

0.050

SDF-1α

268.74 (253.62, 357.07)

219.86 (181.17, 275.33)

0.017

309.99 (234.09, 339.68)

211.88 (190.64, 251.72)

0.008

SCF

37.10 (27.55, 46.29)

47.10 (32.85, 55.57)

0.456

42.94 (28.96, 50.35)

40.35 (26.53, 56.04)

0.960

M-CSF

33.51 (25.14, 38.47)

35.26 (26.15, 49.94)

0.700

31.64 (22.22,42.16)

37.66 (27.04, 50.64)

0.275

G-CSF

70.18 (68.86, 89.17)

45.96 (39.89, 52.46)

0.001

89.49 (73.15, 97.55)

49.40 (36.56, 62.44)

< 0.001

GM-CSF

0.79 (0.61, 1.25)

0.60 (0.01, 1.13)

0.255

1.03 (0.70, 2.37)

0.77 (0.14, 1.33)

0.122

VEGF-A

30.46 (19.20, 52.30)

10.62 (3.37, 15.07)

0.006

46.18 (38.72, 62.85)

13.34 (3.37, 23.12)

< 0.001

Basic FGF

19.51 (19.51, 27.46)

9.91 (7.71, 11.27)

< 0.001

23.62 (20.22, 25.25)

11.60 (7.52, 17.13)

< 0.001

β-NGF

0.74 (0.38, 0.92)

0.47 (0.15, 0.74)

0.226

0.88 (0.74, 1.51)

0.56 (0.28, 0.74)

0.002

SCGF-β

43,169.60 (38,013.20, 57,726.50)

40,842.80 (25,219.40, 45,309.10)

0.316

43,618.70 (38,251.70, 50,595.10)

41,198.40 (34,222.50, 49,973.30)

0.513

HGF

256.86 (249.02,352.46)

227.92 (173.75, 340.78)

0.292

245.12 (213.87, 301.36)

229.34 (160.76, 297.97)

0.557

IFN-α2

5.61 (4.07, 9.52)

4.35 (2.73, 4.90)

0.060

8.14 (6.93, 10.77)

4.71 (2.95, 5.85)

< 0.001

IFN-γ

26.08 (18.59,31.97)

9.48 (8.21, 14.39)

< 0.001

20.89 (17.76, 33.82)

14.41 (9.16, 16.86)

< 0.001

TNF-α

13.98 (12.53,16.84)

9.60 (6.47,13.04)

0.009

15.89 (14.22, 17.78)

8.97 (7.94, 12.41)

< 0.001

TRAIL

35.54 (34.96,55.72)

28.38 (20.62, 33.46)

0.002

40.94 (35.11, 44.48)

32.11 (30.12, 38.04)

0.019

IL-1α

9.96 (8.44, 11.48)

4.23 (1.86, 4.92)

< 0.001

16.45 (11.86, 22.98)

5.51 (3.21, 7.47)

< 0.001

IL-1β

2.90 (2.17, 3.26)

1.88 (1.40, 3.69)

0.316

2.16 (1.59, 3.41)

2.10 (1.38, 2.97)

0.603

IL-1ra

164.78 (145.93, 185.71)

70.70 (55.80, 128.01)

0.004

173.64 (157.39, 185.69)

107.36 (80.87, 150.82)

< 0.001

IL-2Rα

99.66 (83.29, 122.15)

95.46 (76.73, 141.57)

0.857

76.25 (47.30, 115.92)

101.79 (67.09, 133.93)

0.268

IL-4

2.18 (2.01, 2.59)

0.35 (0.17, 0.51)

< 0.001

2.34 (1.94, 3.01)

0.52 (0.39, 1.42)

< 0.001

IL-6

0.91 (0.56, 1.63)

0.65 (0.16, 0.93)

0.246

1.39 (1.01,2.45)

0.91 (0.26, 1.25)

0.021

IL-8

4.75 (3.46, 6.61)

2.28 (1.57, 3.16)

0.003

6.04 (4.40, 7.19)

3.14 (2.15, 4.36)

< 0.001

IL-9

58.55 (51.44, 65.08)

29.50 (26.06, 32.90)

0.001

65.00 (53.56, 69.74)

30.86 (24.88, 41.36)

< 0.001

IL-13

3.70 (2.31, 3.92)

1.94 (1.14, 5.21)

0.440

2.79 (2.00, 4.69)

2.23 (1.59, 4.70)

0.314

IL-16

41.51 (40.09, 49.67)

32.48 (28.14, 53.88)

0.341

37.98 (22.49, 52.19)

32.30 (25.81, 41.78)

0.535

IL-17A

5.12 (4.50, 5.90)

2.47 (1.16, 3.73)

0.013

6.68 (6.05, 8.09)

3.90 (2.39, 5.12)

< 0.001

IL-18

41.61 (35.17, 57.57)

40.37 (30.12, 102.04)

0.857

33.54 (26.08, 42.52)

29.43 (24.75, 58.68)

0.801