Table 3 Predicting value of the baseline (T0) serum cytokines levels on active TB development among untreated controls
Cytokine | AUC (95%CI) | p for z-test | Cut-off (pg/ml) | Sensitivity,% (95% CI) | Specificity,% (95% CI) |
|---|---|---|---|---|---|
Eotaxin | 0.95 (0.87, 1.03) | <0.001 | 50.54 | 88.89 (51.75, 99.72) | 94.44 (72.71, 99.86) |
Basic FGF | 0.96 (0.88, 1.02) | <0.001 | 17.49 | 88.89 (51.75, 99.72) | 94.44 (72.71, 99.86) |
G-CSF | 0.89 (0.76, 1.02) | 0.001 | 58.89 | 88.89 (51.75, 99.72) | 88.89 (65.29, 98.62) |
IFN-γ | 0.95 (0.87, 1.03) | <0.001 | 17.41 | 88.89 (51.75, 99.72) | 94.44 (72.71, 99.86) |
IL-1α | 0.92 (0.82, 1.02) | 0.001 | 8.06 | 88.89 (51.75, 99.72) | 88.89 (65.29, 98.62) |
IL-1ra | 0.85 (0.70, 1.00) | 0.003 | 114.70 | 100.00 (66.37, 100.00) | 72.22 (46.52, 90.31) |
IL-4 | 1.00 (1.00, 1.00) | <0.001 | 1.16 | 100.00 (66.37,100.00) | 100.00 (81.47,100.00) |
IL-8 | 0.86 (0.73, 1.00) | 0.002 | 3.44 | 77.78 (39.99, 97.19) | 83.33 (58.58, 96.42) |
IL-9 | 0.90 (0.77, 1.04) | 0.001 | 38.85 | 88.89 (51.75, 99.72) | 94.44 (72.71, 99.86) |
IL-17A | 0.80 (0.63, 0.98) | <0.001 | 3.48 | 100.00 (66.37, 100.00) | 72.22 (46.52, 90.31) |
MCP-1(MCAF) | 0.79 (0.59, 0.99) | 0.016 | 10.34 | 66.67 (29.93, 92.51) | 83.33 (58.58, 96.42) |
MIP-1β | 0.75 (0.55, 0.94) | 0.040 | 57.65 | 55.56 (21.20, 86.30) | 94.44 (72.71, 99.86) |
SDF-1α | 0.79 (0.61, 0.97) | 0.016 | 218.00 | 100.00 (66.37, 100.00) | 50.00 (26.02, 73.98) |
TNF-α | 0.82 (0.66, 0.97) | 0.009 | 10.48 | 100.00 (66.37, 100.00) | 61.11 (35.75, 82.70) |
TRAIL | 0.88 (0.74, 1.01) | 0.002 | 34.51 | 77.78 (39.99, 97.19) | 88.89 (65.29, 98.62) |
VEGF-A | 0.83 (0.66, 1.00) | 0.006 | 14.31 | 88.89 (51.75, 99.72) | 72.22 (46.52, 90.31) |