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Table 3 Drug-resistant profiles of all enrolled patients stratified by age groups

From: Age-stratified anti-tuberculosis drug resistance profiles in South Korea: a multicenter retrospective study

 

15–34

(n = 734)

35–59

(n = 1593)

≥60

(n = 2090)

Total

(n = 4417)

p-value

Any drug resistance

118 (16.1%)

258 (16.2%)

308 (14.7%)

684 (15.5%)

0.426

Resistant to

 INH

82 (11.2%)

195 (12.2%)

218 (10.4%)

495 (11.2%)

0.226

 RIF

63 (8.6%)

101 (6.3%)

68 (3.3%)

232 (5.3%)

0.000

 Rfb

41 (5.6%)

64 (4.0%)

41 (2.0%)

146 (3.3%)

0.000

 EMB

22 (3.0%)

65 (4.1%)

44 (2.1%)

131 (3.0%)

0.002

 PZA

16 (2.2%)

43 (2.7%)

30 (1.4%)

89 (2.0%)

0.024

 Km

4 (0.5%)

14 (0.9%)

13 (0.6%)

31 (0.7%)

0.558

 Am

4 (0.5%)

11 (0.7%)

12 (0.6%)

27 (0.6%)

0.876

 Cm

5 (0.7%)

12 (0.8%)

17 (0.8%)

34 (0.8%)

0.936

 Sm

31 (4.2%)

61 (3.8%)

76 (3.6%)

168 (3.8%)

0.773

 Lfx

15 (2.0%)

28 (1.8%)

30 (1.4%)

73 (1.7%)

0.495

 Mfx

14 (1.9%)

22 (1.4%)

28 (1.3%)

64 (1.4%)

0.520

 Ofx

15 (2.0%)

27 (1.7%)

29 (1.4%)

71 (1.6%)

0.450

 Pto

8 (1.1%)

14 (0.9%)

23 (1.1%)

45 (1.0%)

0.785

 Cs

1 (0.1%)

3 (0.2%)

2 (0.1%)

6 (0.1%)

0.751

 PAS

5 (0.7%)

24 (1.5%)

29 (1.4%)

58 (1.3%)

0.245

INH-monoresistance

40 (5.4%)

114 (7.2%)

162 (7.8%)

316 (7.2%)

0.115

RIF-monoresistance

21 (2.9%)

20 (1.3%)

12 (0.6%)

53 (1.2%)

0.000

Multidrug resistance

42 (5.7%)

81 (5.1%)

56 (2.7%)

179 (4.1%)

0.000

Resistance to any FQsa

16 (2.2%)

29 (1.8%)

30 (1.4%)

75 (1.7%)

0.363

Resistance to any SLIDsb

7 (1.0%)

16 (1.0%)

19 (0.9%)

42 (1.0%)

0.957

  1. Abbreviations: INH isoniazid, RIF rifampicin, Rfb rifabutin, EMB ethambutol, PZA pyrazinamide, Km kanamycin, Am amikacin, Cm capreomycin, Sm streptomycin, Lfx levofloxacin, Mfx moxifloxacin, Ofx ofloxacin, Pto prothionamide, Cs cycloserine, PAS para-aminosalicylic acid, FQs fluoroquinolones, SLIDs second-line injectable drugs
  2. aAny fluoroquinolones refer to levofloxacin, moxifloxacin, or ofloxacin
  3. bAny second-line injectable drugs refer to kanamycin, amikacin, or capreomycin