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Table 5 Drug-resistant profiles of retreatment patients stratified by age groups

From: Age-stratified anti-tuberculosis drug resistance profiles in South Korea: a multicenter retrospective study

 

15–34

(n = 68)

35–59

(n = 275)

≥60

(n = 354)

Total

(n = 697)

p-value

Any drug resistance

27 (39.7%)

69 (25.1%)

78 (22.0%)

174 (25.0%)

0.009

Resistant to

 INH

20 (29.4%)

55 (20.0%)

65 (18.4%)

140 (20.1%)

0.114

 RIF

22 (32.4%)

47 (17.1%)

26 (7.3%)

95 (13.6%)

0.000

 Rfb

10 (14.7%)

31 (11.3%)

13 (3.7%)

54 (7.7%)

0.000

 EMB

7 (10.3%)

27 (9.8%)

15 (4.2%)

49 (7.0%)

0.014

 PZA

5 (7.4%)

21 (7.6%)

9 (2.5%)

35 (5.0%)

0.010

 Km

2 (2.9%)

9 (3.3%)

2 (0.6%)

13 (1.9%)

0.036

 Am

2 (2.9%)

6 (2.2%)

2 (0.6%)

10 (1.4%)

0.131

 Cm

2 (2.9%)

7 (2.5%)

2 (0.6%)

11 (1.6%)

0.090

 Sm

5 (7.4%)

15 (5.5%)

17 (4.8%)

37 (5.3%)

0.685

 Lfx

7 (10.3%)

10 (3.6%)

12 (3.4%)

29 (4.2%)

0.028

 Mfx

7 (10.3%)

8 (2.9%)

11 (3.1%)

26 (3.7%)

0.011

 Ofx

7 (10.3%)

9 (3.3%)

12 (3.4%)

28 (4.0%)

0.021

 Pto

2 (2.9%)

8 (2.9%)

5 (1.4%)

15 (2.2%)

0.393

 Cs

1 (1.5%)

2 (0.7%)

1 (0.3%)

4 (0.6%)

0.450

 PAS

2 (2.9%)

10 (3.6%)

5 (1.4%)

17 (2.4%)

0.192

INH-monoresistance

4 (5.9%)

15 (5.5%)

40 (11.3%)

59 (8.5%)

0.024

RIF-monoresistance

6 (8.8%)

7 (2.5%)

1 (0.3%)

14 (2.0%)

0.000

Multidrug resistance

16 (23.5%)

40 (14.5%)

25 (7.1%)

81 (11.6%)

0.000

Resistance to any FQsa

7 (10.3%)

11 (4.0%)

12 (3.4%)

30 (4.3%)

0.035

Resistance to any SLIDsb

2 (2.9%)

10 (3.6%)

2 (0.6%)

14 (2.0%)

0.021

  1. Abbreviations: INH isoniazid, RIF rifampicin, Rfb rifabutin, EMB ethambutol, PZA pyrazinamide, Km kanamycin, Am amikacin, Cm capreomycin, Sm streptomycin, Lfx levofloxacin, Mfx moxifloxacin, Ofx ofloxacin, Pto prothionamide, Cs cycloserine, PAS para-aminosalicylic acid, FQs fluoroquinolones, SLIDs second-line injectable drugs
  2. aAny fluoroquinolones refer to levofloxacin, moxifloxacin, or ofloxacin
  3. bAny second-line injectable drugs refer to kanamycin, amikacin, or capreomycin