Day 1 to Day 14 | Day 15 after anti-tuberculosis initiation | Day 14 after combined treatment (anti-TB and ART) | |
---|---|---|---|
arm | Anti-tuberculosis alone | Combined anti-tuberculosis and ART (for the duration of anti-TB therapy) | Pharmacokinetic monitoring |
A | “300 mg rifabutin + standard ethambutol-isoniazid-pyrazinamide regimen” daily for 14 days | 150 mg rifabutin every other day + standard ethambutol-isoniazid-pyrazinamide regimen combined with ART regimen including 200/50 mg lopinavir/ritonavir taken twice daily | Blood taken for pharmacokinetic monitoring |
B | “300 mg rifabutin + standard ethambutol-isoniazid-pyrazinamide regimen” daily for 14 days | 300 mg rifabutin every other day + standard ethambutol-isoniazid-pyrazinamide regimen combined with ART regimen including 200/50 mg lopinavir/ritonavir taken twice daily | Blood taken for pharmacokinetic monitoring |