Table 3 Comparison of pharmacokinetic parameters between 150 mg rifabutin and 300 mg rifabutin combined with lopinavir/ritonavir (200/50 mg)

 Ctrough (ng/mL)

53 (46–78)

177 (94–266)

 Cmax (ng/mL)

296 (205–450)

600 (403–717)

 Tmax (h)

3 (2–6)

4 (2–4)

 AUC_{0–12 h}

2528 (1684–2735)

4042.5 (3469–5761)

 CL (L/h)

51.5 (34.1–53.0)

23.2 (20.1–24.9)

 CL (L/h/kg)

0.92 (0.63–1.02)

0.84 (0.78–1.00)

 Ctrough (ng/mL)

61 (39–65)

103 (79–126)

 Cmax (ng/mL)

129 (111–157)

160 (136–345)

 Tmax (h)

6 (2–8)

3 (3–4)

 AUC_{0–12 h} (ng.h/mL)

1200.5 (737.5–1295.5)

1534 (1059.5–2351)