Skip to main content

Table 4 Geometric means ratio of plasma RBT and d-RBT concentrations after the administration of RBT (150 mg or 300 mg EOD) combined with lopinavir/ritonavir (200 mg/50 mg)

From: Pharmacokinetic study of two different rifabutin doses co-administered with lopinavir/ritonavir in African HIV and tuberculosis co-infected adult patients

Plasma RBT concentration (ng/mL)GMR (150 mg RBT/300 mg RBT)95%CIpvalue
Cmax0.4730.2640.8470.015
Tmax0.8410.4641.5220.540
AUC0–12h0.5100.3150.8230.009
Plasma d-RBT concentration (ng/mL)
 Cmax0.5440.3030.9770.042
 Tmax1.2540.6152.5590.507
 AUC0–120.5970.3330.8300.009
  1. Abbreviations: GMR geometric means ratio, RBT rifabutin, d-RBT 25-O-desacetyl-rifabutin, EOD every other day