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Table 4 Geometric means ratio of plasma RBT and d-RBT concentrations after the administration of RBT (150 mg or 300 mg EOD) combined with lopinavir/ritonavir (200 mg/50 mg)

From: Pharmacokinetic study of two different rifabutin doses co-administered with lopinavir/ritonavir in African HIV and tuberculosis co-infected adult patients

Plasma RBT concentration (ng/mL)

GMR (150 mg RBT/300 mg RBT)

95%CI

pvalue

Cmax

0.473

0.264

0.847

0.015

Tmax

0.841

0.464

1.522

0.540

AUC0–12h

0.510

0.315

0.823

0.009

Plasma d-RBT concentration (ng/mL)

 Cmax

0.544

0.303

0.977

0.042

 Tmax

1.254

0.615

2.559

0.507

 AUC0–12

0.597

0.333

0.830

0.009

  1. Abbreviations: GMR geometric means ratio, RBT rifabutin, d-RBT 25-O-desacetyl-rifabutin, EOD every other day